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Most malignant melanomas, thyroid and testicular cancers showed moderate positivity. Malignant cells in general exhibited weak staining or were negative.
GENE INFORMATION
Gene name
ICOS (HGNC Symbol)
Synonyms
AILIM, CD278
Description
Inducible T-cell co-stimulator (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]