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Most cancer tissues showed moderate to strong granular cytoplasmic positivity. A majority of renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
WDFY3 (HGNC Symbol)
Synonyms
ALFY, KIAA0993, ZFYVE25
Description
WD repeat and FYVE domain containing 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]