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Most cancer tissues displayed moderate cytoplasmic staining with a granular pattern, in several cases combined with membranous positivity. Several cases of lymphomas, colorectal and endometrial cancers showed strong immunoreactivity. Several renal cancers were negative.
Several colorectal cancers as well as a few cases of breast and ovarian cancers displayed weak to moderate cytoplasmic and sometimes nuclear positivity. Strong cytoplasmic immunoreactivity was observed in a subset of cells in cases of renal cancers. Most cancer tissues were weakly stained or negative.