We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Many hepatocellular carcinomas and renal cancers along with a few malignant melanomas and pancreatic cancers displayed moderate to strong cytoplasmic immunoreactivity. A few urothelial, endometrial, cervical and breast cancers were moderately stained. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
VKORC1 (HGNC Symbol)
Synonyms
VKCFD2
Description
Vitamin K epoxide reductase complex, subunit 1 (HGNC Symbol)
Entrez gene summary
This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]