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A few cases of lymphomas and endometrial cancers displayed strong cytoplasmic positivity. Most pancreatic cancers, several hepatocellular carcinomas and renal cancers showed moderate immunoreactivity. Remaining cancer cells generally displayed weak staining or were negative.
GENE INFORMATION
Gene name
TRIM8 (HGNC Symbol)
Synonyms
GERP, RNF27
Description
Tripartite motif containing 8 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]