Cell atlas - LRRC8D - The Human Protein Atlas

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LRRC8D

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	LRRC8D
Gene description	Leucine rich repeat containing 8 family, member D
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA014745
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the mitochondria.

Main location

Nucleoplasm (approved)

Additional location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014745	A-431	Nucleoplasm
	HPA014745	A-431	Mitochondria
	HPA014745	U-2 OS	Nucleoplasm	Intensity
	HPA014745	U-251 MG	Nucleoplasm
	HPA014745	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	LRRC8D (HGNC Symbol)
Synonyms	FLJ10470, LRRC5
Description	Leucine rich repeat containing 8 family, member D (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p22.2
Chromosome location (bp)	89821014 - 89936611
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171492 (version 83.38)
Entrez gene	55144
UniProt	Q7L1W4 (UniProt - Evidence at protein level)
neXtProt	NX_Q7L1W4
Antibodypedia	LRRC8D antibodies

PROTEIN BROWSER

LRRC8D-001	LRRC8D-002	LRRC8D-003	LRRC8D-004	LRRC8D-005	LRRC8D-006	LRRC8D-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC8D-001 ENSP00000338887 ENST00000337338	Q7L1W4 [Direct mapping] Volume-regulated anion channel subunit LRRC8D Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	858 aa 98.2 kDa	No	4
LRRC8D-002 ENSP00000378093 ENST00000394593	Q7L1W4 [Direct mapping] Volume-regulated anion channel subunit LRRC8D Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	858 aa 98.2 kDa	No	4
LRRC8D-003 ENSP00000415117 ENST00000414841	Q5VWA0 [Direct mapping] Volume-regulated anion channel subunit LRRC8D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	117 aa 12.9 kDa	No	1
LRRC8D-004 ENSP00000435609 ENST00000525774	E9PJ89 [Direct mapping] Volume-regulated anion channel subunit LRRC8D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.8 kDa	No	0
LRRC8D-005 ENSP00000435504 ENST00000532201	E9PJS7 [Direct mapping] Volume-regulated anion channel subunit LRRC8D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	122 aa 13.4 kDa	No	1
LRRC8D-006 ENSP00000433422 ENST00000527156	E9PL08 [Direct mapping] Volume-regulated anion channel subunit LRRC8D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	187 aa 21.3 kDa	No	2
LRRC8D-007 ENSP00000405784 ENST00000441269	E9PMF9 [Direct mapping] Volume-regulated anion channel subunit LRRC8D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	274 aa 30.7 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.