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CTNNBIP1

GENERAL INFORMATION

Gene name

 CTNNBIP1

Gene description

 Catenin, beta interacting protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CTNNBIP1 (HGNC Symbol)

Synonyms

 ICAT, MGC15093

Description

 Catenin, beta interacting protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 9848276 - 9910336

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178585 (version 83.38)

Entrez gene

 56998

UniProt

 Q9NSA3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSA3

Antibodypedia

 CTNNBIP1 antibodies

PROTEIN BROWSER
CTNNBIP1-001
CTNNBIP1-002
CTNNBIP1-003
CTNNBIP1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTNNBIP1-001
ENSP00000366474
ENST00000377263
Q9NSA3 [Direct mapping]
Beta-catenin-interacting protein 1
A0A024R4D7 [Target identity:100%; Query identity:100%]
Catenin, beta interacting protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0002528 [regulation of vascular permeability involved in acute inflammatory response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0009952 [anterior/posterior pattern specification]
GO:0016055 [Wnt signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030877 [beta-catenin destruction complex]
GO:0031333 [negative regulation of protein complex assembly]
GO:0032091 [negative regulation of protein binding]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0060633 [negative regulation of transcription initiation from RNA polymerase II promoter]
GO:0070016 [armadillo repeat domain binding]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
Show all
 81 aa
9.2 kDa 		No 0
CTNNBIP1-002
ENSP00000383696
ENST00000400904
Q9NSA3 [Direct mapping]
Beta-catenin-interacting protein 1
A0A024R4D7 [Target identity:100%; Query identity:100%]
Catenin, beta interacting protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0002528 [regulation of vascular permeability involved in acute inflammatory response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0009952 [anterior/posterior pattern specification]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030877 [beta-catenin destruction complex]
GO:0032091 [negative regulation of protein binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
Show all
 81 aa
9.2 kDa 		No 0
CTNNBIP1-003
ENSP00000366468
ENST00000377258
Q9NSA3 [Direct mapping]
Beta-catenin-interacting protein 1
A0A024R4D7 [Target identity:100%; Query identity:100%]
Catenin, beta interacting protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0002528 [regulation of vascular permeability involved in acute inflammatory response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0009952 [anterior/posterior pattern specification]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030877 [beta-catenin destruction complex]
GO:0032091 [negative regulation of protein binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
Show all
 81 aa
9.2 kDa 		No 0
CTNNBIP1-004
ENSP00000366466
ENST00000377256
Q9NSA3 [Direct mapping]
Beta-catenin-interacting protein 1
A0A024R4D7 [Target identity:100%; Query identity:100%]
Catenin, beta interacting protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0002528 [regulation of vascular permeability involved in acute inflammatory response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0009952 [anterior/posterior pattern specification]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030877 [beta-catenin destruction complex]
GO:0032091 [negative regulation of protein binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
Show all
 81 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.