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Cancer tissues displayed weak to moderate nuclear staining with additional membranous and/or cytoplasmic positivity in few cases. Several cases of cervical cancers along with a rare case of ovarian cancer were strongly positive. Majority of the cases of gliomas and prostate cancers were negative.
GENE INFORMATION
Gene name
TREX2
Synonyms
Description
Three prime repair exonuclease 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]