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Most cancer cells displayed moderate cytoplasmic and/or nuclear staining. Several testicular and colorectal cancers as well as a few gliomas, lymphomas, melanomas, skin and urothelial cancers were strongly stained. A majority of renal and liver cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SUMO3 (HGNC Symbol)
Synonyms
SMT3A, SMT3H1
Description
Small ubiquitin-like modifier 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]