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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

CLN3

Gene descriptioni

Gene description according to HGNC.

Ceroid-lipofuscinosis, neuronal 3

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular,Membrane

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

18
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue categoryi

The RNA tissue category is based on mRNA expression levels in the analyzed tissues (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA tissue category is calculated separately both for internally generated Human Protein Atlas (HPA) RNA-seq data, as well as RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project.

Read more

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expressioni

A summary of the overall protein expression pattern across the analyzed tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Cytoplasmic expression in a number of tissues, most prominent in smooth muscle.

DATA RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining mainly not consistent with RNA expression data.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Uncertain based on 1 antibody.
HPA063280
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARYi

Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page. Images of selected tissues give a visual summary of the protein expression profile furthest to the right. The gray human body provides links to a histology dictionary when clicking on any part of the figure.

RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.

Read more
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEWi

Protein expression data is shown for each of the 44 tissues. The color-coding is based on tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.

For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.

HPA dataseti

HPA dataset
RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.

RNA tissue category HPA
HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti

GTEx dataset
RNA-seq data are reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.

RNA tissue category GTEx
GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti

FANTOM5 dataset
Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.

RNA tissue category FANTOM5
FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

CLN3 (HGNC Symbol)

Synonyms

BTS, JNCL

Description

Ceroid-lipofuscinosis, neuronal 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p12.1

Chromosome location (bp)

28477279 - 28495575

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188603 (version 83.38)

Entrez gene

1201

UniProt

Q13286 (UniProt - Evidence at protein level)

neXtProt

NX_Q13286

Antibodypedia

CLN3 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

«
CLN3-001
CLN3-005
CLN3-006
CLN3-007
CLN3-008
CLN3-009
CLN3-012
CLN3-014
CLN3-017
CLN3-020
CLN3-027
CLN3-030
CLN3-031
CLN3-201
CLN3-202
CLN3-203
CLN3-204
CLN3-205
»

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLN3-001
ENSP00000454229
ENST00000569430
Q13286 [Direct mapping]
Battenin
A0A024QZB8 [Target identity:100%; Query identity:100%]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001508 [action potential]
GO:0001575 [globoside metabolic process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006520 [cellular amino acid metabolic process]
GO:0006672 [ceramide metabolic process]
GO:0006678 [glucosylceramide metabolic process]
GO:0006681 [galactosylceramide metabolic process]
GO:0006684 [sphingomyelin metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0007042 [lysosomal lumen acidification]
GO:0008021 [synaptic vesicle]
GO:0008306 [associative learning]
GO:0015809 [arginine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016236 [macroautophagy]
GO:0016242 [negative regulation of macroautophagy]
GO:0016485 [protein processing]
GO:0030163 [protein catabolic process]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035752 [lysosomal lumen pH elevation]
GO:0042133 [neurotransmitter metabolic process]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045121 [membrane raft]
GO:0045861 [negative regulation of proteolysis]
GO:0047496 [vesicle transport along microtubule]
GO:0050885 [neuromuscular process controlling balance]
GO:0051082 [unfolded protein binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0061024 [membrane organization]
GO:0097352 [autophagosome maturation]
Show all
438 aa
47.6 kDa
No 9
CLN3-005
ENSP00000455387
ENST00000567963
H3BPM8 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
341 aa
36.3 kDa
No 6
CLN3-006
ENSP00000329171
ENST00000333496
Q13286 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001508 [action potential]
GO:0001575 [globoside metabolic process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006520 [cellular amino acid metabolic process]
GO:0006672 [ceramide metabolic process]
GO:0006678 [glucosylceramide metabolic process]
GO:0006681 [galactosylceramide metabolic process]
GO:0006684 [sphingomyelin metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0007042 [lysosomal lumen acidification]
GO:0008021 [synaptic vesicle]
GO:0008306 [associative learning]
GO:0015809 [arginine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016236 [macroautophagy]
GO:0016242 [negative regulation of macroautophagy]
GO:0016485 [protein processing]
GO:0030163 [protein catabolic process]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035752 [lysosomal lumen pH elevation]
GO:0042133 [neurotransmitter metabolic process]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045121 [membrane raft]
GO:0045861 [negative regulation of proteolysis]
GO:0047496 [vesicle transport along microtubule]
GO:0050885 [neuromuscular process controlling balance]
GO:0051082 [unfolded protein binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0061024 [membrane organization]
GO:0097352 [autophagosome maturation]
Show all
414 aa
45.2 kDa
No 9
CLN3-007
ENSP00000379014
ENST00000395653
B4DMY6 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
338 aa
37 kDa
No 8
CLN3-008
ENSP00000350457
ENST00000357806
Q13286 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001508 [action potential]
GO:0001575 [globoside metabolic process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006520 [cellular amino acid metabolic process]
GO:0006672 [ceramide metabolic process]
GO:0006678 [glucosylceramide metabolic process]
GO:0006681 [galactosylceramide metabolic process]
GO:0006684 [sphingomyelin metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0007042 [lysosomal lumen acidification]
GO:0008021 [synaptic vesicle]
GO:0008306 [associative learning]
GO:0015809 [arginine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016236 [macroautophagy]
GO:0016242 [negative regulation of macroautophagy]
GO:0016485 [protein processing]
GO:0030163 [protein catabolic process]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035752 [lysosomal lumen pH elevation]
GO:0042133 [neurotransmitter metabolic process]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045121 [membrane raft]
GO:0045861 [negative regulation of proteolysis]
GO:0047496 [vesicle transport along microtubule]
GO:0050885 [neuromuscular process controlling balance]
GO:0051082 [unfolded protein binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0061024 [membrane organization]
GO:0097352 [autophagosome maturation]
Show all
339 aa
38 kDa
No 6
CLN3-009
ENSP00000455603
ENST00000568558
H3BQ48 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
184 aa
20.7 kDa
No 1
CLN3-012
ENSP00000350523
ENST00000357857
B4DFF3 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
384 aa
41.6 kDa
No 8
CLN3-014
ENSP00000458015
ENST00000565778
O95090 [Direct mapping]
Battenin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
Show all
167 aa
18.5 kDa
No 0
CLN3-017
ENSP00000454899
ENST00000568443
H3BNK7 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
Show all
175 aa
18.9 kDa
No 2
CLN3-020
ENSP00000456117
ENST00000565316
Q13286 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001508 [action potential]
GO:0001575 [globoside metabolic process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006520 [cellular amino acid metabolic process]
GO:0006672 [ceramide metabolic process]
GO:0006678 [glucosylceramide metabolic process]
GO:0006681 [galactosylceramide metabolic process]
GO:0006684 [sphingomyelin metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0007042 [lysosomal lumen acidification]
GO:0008021 [synaptic vesicle]
GO:0008306 [associative learning]
GO:0015809 [arginine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016236 [macroautophagy]
GO:0016242 [negative regulation of macroautophagy]
GO:0016485 [protein processing]
GO:0030163 [protein catabolic process]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035752 [lysosomal lumen pH elevation]
GO:0042133 [neurotransmitter metabolic process]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045121 [membrane raft]
GO:0045861 [negative regulation of proteolysis]
GO:0047496 [vesicle transport along microtubule]
GO:0050885 [neuromuscular process controlling balance]
GO:0051082 [unfolded protein binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0061024 [membrane organization]
GO:0097352 [autophagosome maturation]
Show all
421 aa
45.6 kDa
No 8
CLN3-027
ENSP00000455365
ENST00000567804
H3BPL0 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
74 aa
8.2 kDa
No 1
CLN3-030
ENSP00000456122
ENST00000565688
H3BR84 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
176 aa
18.3 kDa
No 4
CLN3-031
ENSP00000457615
ENST00000561505
H3BUF8 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
121 aa
12.5 kDa
No 3
CLN3-201
ENSP00000347660
ENST00000355477
Q9UBD8 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
181 aa
19.3 kDa
No 3
CLN3-202
ENSP00000353073
ENST00000359984
O95086 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
336 aa
36.8 kDa
No 7
CLN3-203
ENSP00000353116
ENST00000360019
Q13286 [Direct mapping]
Battenin
A0A024QZB8 [Target identity:100%; Query identity:100%]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001508 [action potential]
GO:0001575 [globoside metabolic process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006520 [cellular amino acid metabolic process]
GO:0006672 [ceramide metabolic process]
GO:0006678 [glucosylceramide metabolic process]
GO:0006681 [galactosylceramide metabolic process]
GO:0006684 [sphingomyelin metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0007042 [lysosomal lumen acidification]
GO:0008021 [synaptic vesicle]
GO:0008306 [associative learning]
GO:0015809 [arginine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016236 [macroautophagy]
GO:0016242 [negative regulation of macroautophagy]
GO:0016485 [protein processing]
GO:0030163 [protein catabolic process]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035752 [lysosomal lumen pH elevation]
GO:0042133 [neurotransmitter metabolic process]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045121 [membrane raft]
GO:0045861 [negative regulation of proteolysis]
GO:0047496 [vesicle transport along microtubule]
GO:0050885 [neuromuscular process controlling balance]
GO:0051082 [unfolded protein binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0061024 [membrane organization]
GO:0097352 [autophagosome maturation]
Show all
438 aa
47.6 kDa
No 9
CLN3-204
ENSP00000486178
ENST00000628023
H3BRU8 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
82 aa
9.1 kDa
No 1
CLN3-205
ENSP00000486616
ENST00000631023
H3BPM8 [Direct mapping]
Battenin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005765 [lysosomal membrane]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
341 aa
36.3 kDa
No 6

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