We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Moderate to strong cytoplasmic positivity was observed in most melanomas, gliomas, testis, urothelial and head and neck cancers, along with few cases of most other cancers. Tumour stroma was distinctly stained. Lymphomas, cervical, lung and stomach cancers were negative.
Tumor cells were either weakly stained in the cytoplasm or less frequently in the nucleus and membrane or negative in most cases. Glioma, lymphoma, melanoma, ovarian and endometrial cancer showed moderate positivity in a few cases.
GENE INFORMATION
Gene name
KAZN (HGNC Symbol)
Synonyms
FLJ43806, KAZRIN, KIAA1026
Description
Kazrin, periplakin interacting protein (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]