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Several cases of malignant lymphomas, cervical, endometrial and head & neck cancers along with a few cases of malignant melanomas, colorectal, ovarian and gastric cancers exhibited moderate cytoplasmic and occasional membranous positivity. Strong staining was observed in a few lung and endometrial cancers. Inflammatory cells in the stroma were distinctly stained. Remaining malignant cells were mainly negative.
Several non-Hodgkins lymphomas and fractions of cases in squamous cell carcinomas, ductal breas cancers and female genital cancers exhibited moderate to strong cytoplasmic immunoreactivity. Remaining tumors were negative.
GENE INFORMATION
Gene name
HLA-DRB1 (HGNC Symbol)
Synonyms
HLA-DR1B
Description
Major histocompatibility complex, class II, DR beta 1 (HGNC Symbol)
Entrez gene summary
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
P01911 (UniProt - Evidence at protein level), P04229 (UniProt - Evidence at protein level), Q29974 (UniProt - Evidence at protein level), Q9GIY3 (UniProt - Evidence at protein level)
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042613 [MHC class II protein complex]