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Most of the malignant cells displayed weak to moderate membranous and/or cytoplasmic staining with additional nuclear immunoreactivity in some cases. A few non-Hodgkins lymphomas, colorectal, ovarian and urothelial cancers were strongly stained. Many malignant gliomas, breast, prostate, endometrial and renal cancers were negative.
GENE INFORMATION
Gene name
SPANXD (HGNC Symbol)
Synonyms
CT11.4, SPANXE
Description
SPANX family, member D (HGNC Symbol)
Entrez gene summary
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014]