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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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ADH4
  • premium

    TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLASi

The cancer tissue page shows antibody staining in 20 different cancers. The assay and annotation is described here.

This page starts with information about the protein evidence and, when applicable, also protein class. Below the summary, a selection of four standard cancer tissue samples is displayed as representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional 5th image can be added as a complement.

For histological reference, visit the histological dictionary.

Gene description

Alcohol dehydrogenase 4 (class II), pi polypeptide

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

The cancer tissue summary page shows antibody staining in 20 different cancers. The assay and annotation is described here.

For each cancer, the fraction of samples with antibody staining/protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The tooltip function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

At the bottom of the page, a summary of the overall protein expression pattern across the analyzed cancer tissues as well as information about literature conformity are presented.

HPA020525

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Liver cancers showed weak to moderate cytoplasmic positivity. Remaining cancer tissues were negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

ADH4 (HGNC Symbol)

Synonyms

ADH-2

Description

Alcohol dehydrogenase 4 (class II), pi polypeptide (HGNC Symbol)

Entrez gene summary

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q23

Chromosome location (bp)

99123657 - 99157792

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198099 (version 83.38)

Entrez gene

127

UniProt

P08319 (UniProt - Evidence at protein level)

neXtProt

NX_P08319

Antibodypedia

ADH4 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

ADH4-001
ADH4-002
ADH4-005
ADH4-006
ADH4-011
ADH4-201

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADH4-001
ENSP00000265512
ENST00000265512
P08319 [Direct mapping]
Alcohol dehydrogenase 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003960 [NADPH:quinone reductase activity]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004745 [retinol dehydrogenase activity]
GO:0005503 [all-trans retinal binding]
GO:0005829 [cytosol]
GO:0006066 [alcohol metabolic process]
GO:0006069 [ethanol oxidation]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0019115 [benzaldehyde dehydrogenase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0042572 [retinol metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046164 [alcohol catabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1901661 [quinone metabolic process]
Show all
380 aa
40.2 kDa
No 0
ADH4-002
ENSP00000424630
ENST00000508393
P08319 [Direct mapping]
Alcohol dehydrogenase 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003960 [NADPH:quinone reductase activity]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005503 [all-trans retinal binding]
GO:0005829 [cytosol]
GO:0006066 [alcohol metabolic process]
GO:0006067 [ethanol metabolic process]
GO:0006069 [ethanol oxidation]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0019115 [benzaldehyde dehydrogenase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0042572 [retinol metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046164 [alcohol catabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1901661 [quinone metabolic process]
Show all
399 aa
42.6 kDa
No 0
ADH4-005
ENSP00000425416
ENST00000505590
P08319 [Direct mapping]
Alcohol dehydrogenase 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003960 [NADPH:quinone reductase activity]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004745 [retinol dehydrogenase activity]
GO:0005503 [all-trans retinal binding]
GO:0005829 [cytosol]
GO:0006066 [alcohol metabolic process]
GO:0006069 [ethanol oxidation]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0019115 [benzaldehyde dehydrogenase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0042572 [retinol metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046164 [alcohol catabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1901661 [quinone metabolic process]
Show all
399 aa
42.6 kDa
No 0
ADH4-006
ENSP00000427525
ENST00000504125
D6RIB1 [Direct mapping]
Alcohol dehydrogenase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0006069 [ethanol oxidation]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0035276 [ethanol binding]
GO:0055114 [oxidation-reduction process]
Show all
206 aa
21.5 kDa
No 0
ADH4-011
ENSP00000423571
ENST00000512499
D6R9K8 [Direct mapping]
Alcohol dehydrogenase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0006069 [ethanol oxidation]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0035276 [ethanol binding]
GO:0055114 [oxidation-reduction process]
Show all
257 aa
27.4 kDa
No 0
ADH4-201
ENSP00000486450
ENST00000629236
A0A0D9SFB5 [Direct mapping]
Alcohol dehydrogenase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0006069 [ethanol oxidation]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0035276 [ethanol binding]
GO:0055114 [oxidation-reduction process]
Show all
391 aa
41.6 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.