Tissue expression of DENND4B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DENND4B
Gene description	DENN/MADD domain containing 4B
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DENND4B (HGNC Symbol)
Synonyms	KIAA0476
Description	DENN/MADD domain containing 4B (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	153929501 - 153946696
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198837 (version 83.38)
Entrez gene	9909
UniProt	O75064 (UniProt - Evidence at protein level)
neXtProt	NX_O75064
Antibodypedia	DENND4B antibodies

PROTEIN BROWSER

DENND4B-001	DENND4B-012	DENND4B-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DENND4B-001 ENSP00000354597 ENST00000361217	O75064 [Direct mapping] DENN domain-containing protein 4B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0032483 [regulation of Rab protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1496 aa 163.8 kDa	No	2
DENND4B-012 ENSP00000357635 ENST00000368646	E9PAK5 [Direct mapping] DENN domain-containing protein 4B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		1218 aa 133.4 kDa	No	2
DENND4B-013 ENSP00000435709 ENST00000472932	H0YEF0 [Direct mapping] DENN domain-containing protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		181 aa 18.9 kDa	No	0