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A majority of malignant cells showed weak to moderate cytoplasmic positivity. Strong granular cytoplasmic positivity was observed in all non-Hodgkin’s lymphomas. Endometrial cancers displayed distinct membranous and cytoplasmic staining in a majority of cases.
GENE INFORMATION
Gene name
HLA-DMA (HGNC Symbol)
Synonyms
D6S222E, RING6
Description
Major histocompatibility complex, class II, DM alpha (HGNC Symbol)
Entrez gene summary
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]
P28067 [Direct mapping] HLA class II histocompatibility antigen, DM alpha chain Q31604 [Target identity:100%; Query identity:100%] DMA protein; HLA-DMA protein; MHC class II antigen; Major histocompatibility complex, class II, DM alpha; Major histocompatibility complex, class II, DM alpha, isoform CRA_c; cDNA FLJ75740, highly similar to Homo sapiens major histocompatibility complex, class II, DM alpha (HLA-DMA), mRNA Q6ICR9 [Target identity:100%; Query identity:100%] HLA-DMA protein
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002503 [peptide antigen assembly with MHC class II protein complex] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0005771 [multivesicular body] GO:0006461 [protein complex assembly] GO:0006955 [immune response] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016064 [immunoglobulin mediated immune response] GO:0019882 [antigen processing and presentation] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0023026 [MHC class II protein complex binding] GO:0031902 [late endosome membrane] GO:0042613 [MHC class II protein complex] GO:0045059 [positive thymic T cell selection] GO:0045582 [positive regulation of T cell differentiation] GO:0048839 [inner ear development] GO:0050778 [positive regulation of immune response] GO:0051085 [chaperone mediated protein folding requiring cofactor] GO:0070062 [extracellular exosome]
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042613 [MHC class II protein complex]
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042613 [MHC class II protein complex]
F6S093 [Direct mapping] HLA class II histocompatibility antigen, DM alpha chain
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042613 [MHC class II protein complex]