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Most cancer tissues showed weak to moderate cytoplasmic and in some cases nuclear positivity.. Most lymphomas showed strong cytoplasmic positivity. The majority of gastric, lung, testis, urothelial, renal and liver cancers were negative.
Lymphomas and squamous cell carcinomas generally displayed strong cytoplasmic staining. Prostate, hepatocellular and cases of renal cancers were weakly stained while most other malignancies were moderately stained.
This gene encodes a sterile alpha motif domain-containing protein. The encoded protein localizes to the cytoplasm and may play a role in regulating cell proliferation and apoptosis. Mutations in this gene are the cause of normophosphatemic familial tumoral calcinosis. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jul 2010]