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Malignant cells mostly displayed weak to moderate cytoplasmic and occasional membranous positivity. Malignant glioma, lymphoma, melanoma, renal, prostate and testis cancers were mostly negative.
GENE INFORMATION
Gene name
PARG
Synonyms
Description
Poly (ADP-ribose) glycohydrolase (HGNC Symbol)
Entrez gene summary
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)