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The majority of malignancies exhibited moderate to strong cytoplasmic and nuclear staining. Most urothelial and cervical cancers along with several endometrial, lung, skin, testicular, gastric and pancreatic cancers were weakly stained or negative.
GENE INFORMATION
Gene name
EIF4EBP3 (HGNC Symbol)
Synonyms
4E-BP3
Description
Eukaryotic translation initiation factor 4E binding protein 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]