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Weak to moderate cytoplasmic and occasional membranous positivity was observed in a few skin and rare urothelial cancers. Moderate nuclear or luminal membranous staining was exhibited in a few cases of serous cystadenocarcinomas of ovary. A few cases of colorectal cancers showed weak to moderate membranous staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
TIFAB
Synonyms
Description
TRAF-interacting protein with forkhead-associated domain, family member B (HGNC Symbol)
Entrez gene summary
TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]