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Egl-9 family hypoxia-inducible factor 2 (HGNC Symbol)
Entrez gene summary
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]
Q96KS0 [Direct mapping] Egl nine homolog 2 A0A024R0R2 [Target identity:100%; Query identity:100%] Egl nine homolog 2 (C. elegans), isoform CRA_b
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Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014)
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GO:0001558 [regulation of cell growth] GO:0001666 [response to hypoxia] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008198 [ferrous iron binding] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0019826 [oxygen sensor activity] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031418 [L-ascorbic acid binding] GO:0031545 [peptidyl-proline 4-dioxygenase activity] GO:0043523 [regulation of neuron apoptotic process] GO:0045454 [cell redox homeostasis] GO:0045732 [positive regulation of protein catabolic process] GO:0055114 [oxidation-reduction process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia]
Q96KS0 [Direct mapping] Egl nine homolog 2 A0A024R0R2 [Target identity:100%; Query identity:100%] Egl nine homolog 2 (C. elegans), isoform CRA_b
Show all
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014)
Show all
GO:0001558 [regulation of cell growth] GO:0001666 [response to hypoxia] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008198 [ferrous iron binding] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0019826 [oxygen sensor activity] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031418 [L-ascorbic acid binding] GO:0031545 [peptidyl-proline 4-dioxygenase activity] GO:0043523 [regulation of neuron apoptotic process] GO:0045454 [cell redox homeostasis] GO:0045732 [positive regulation of protein catabolic process] GO:0055114 [oxidation-reduction process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia]
GO:0001558 [regulation of cell growth] GO:0001666 [response to hypoxia] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0008198 [ferrous iron binding] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0019826 [oxygen sensor activity] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031418 [L-ascorbic acid binding] GO:0031543 [peptidyl-proline dioxygenase activity] GO:0031545 [peptidyl-proline 4-dioxygenase activity] GO:0043523 [regulation of neuron apoptotic process] GO:0045454 [cell redox homeostasis] GO:0045732 [positive regulation of protein catabolic process] GO:0055114 [oxidation-reduction process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia]