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Several cases of hepatocellular carcinomas showed moderate to strong cytoplasmic staining. Few cases of duct carcinomas of breast, seminomas, Hodgkin lymphomas, colorectal and pancreatic cancers displayed moderate positivity. Remaining malignant tissues were weakly stained or negative.
Cancer tissues displayed weak to moderate cytoplasmic and occasional nuclear positivity. Several cases of gliomas, lymphomas, renal and prostate cancers were negative.
Several melanomas, stomach, prostate cancers along with few cases of malignant gliomas, breast, liver, ovarian and renal cancers displayed moderate to strong cytoplasmic positivity. Other tissues were weakly stained or generally negative.
Few cases of breast and lung cancers displayed moderate to strong cytoplasmic staining. Occasional cases of prostate, testis, thyroid and colorectal cancers were moderately positive. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
TYW1B (HGNC Symbol)
Synonyms
LINC00069, MGC87315, NCRNA00069, RSAFD2
Description
TRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) (HGNC Symbol)
Entrez gene summary
Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. The human genome contains two closely related genes that putatively function in wybutosine synthesis. The open reading frame of this locus is disrupted in some individuals. Thus, this locus appears to be an evolving pseudogene, but may still be functional in some members of the population. [provided by RefSeq, Apr 2014]