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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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EP300
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    TISSUE

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    CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

EP300

Gene description

E1A binding protein p300

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear and cytoplasmic expression at variable levels in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA003128 , HPA004112 , CAB000146
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

EP300 (HGNC Symbol)

Synonyms

KAT3B, p300

Description

E1A binding protein p300 (HGNC Symbol)

Entrez gene summary

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q13.2

Chromosome location (bp)

41091786 - 41180079

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100393 (version 83.38)

Entrez gene

2033

UniProt

Q09472 (UniProt - Evidence at protein level)

neXtProt

NX_Q09472

Antibodypedia

EP300 antibodies

PROTEIN BROWSER

EP300-001
EP300-005
EP300-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EP300-001
ENSP00000263253
ENST00000263253
Q09472 [Direct mapping]
Histone acetyltransferase p300
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000123 [histone acetyltransferase complex]
GO:0000278 [mitotic cell cycle]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001666 [response to hypoxia]
GO:0001756 [somitogenesis]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0004468 [lysine N-acetyltransferase activity, acting on acetyl phosphate as donor]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006473 [protein acetylation]
GO:0006475 [internal protein amino acid acetylation]
GO:0006915 [apoptotic process]
GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response]
GO:0007219 [Notch signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007519 [skeletal muscle tissue development]
GO:0007623 [circadian rhythm]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0016032 [viral process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0018076 [N-terminal peptidyl-lysine acetylation]
GO:0018393 [internal peptidyl-lysine acetylation]
GO:0030183 [B cell differentiation]
GO:0030220 [platelet formation]
GO:0030324 [lung development]
GO:0031490 [chromatin DNA binding]
GO:0032092 [positive regulation of protein binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0033613 [activating transcription factor binding]
GO:0034605 [cellular response to heat]
GO:0034644 [cellular response to UV]
GO:0035257 [nuclear hormone receptor binding]
GO:0035855 [megakaryocyte development]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0043627 [response to estrogen]
GO:0043923 [positive regulation by host of viral transcription]
GO:0043967 [histone H4 acetylation]
GO:0043969 [histone H2B acetylation]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050681 [androgen receptor binding]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051726 [regulation of cell cycle]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0090043 [regulation of tubulin deacetylation]
GO:0097157 [pre-mRNA intronic binding]
GO:1900034 [regulation of cellular response to heat]
Show all
2414 aa
264.2 kDa
No 0
EP300-005
ENSP00000489397
ENST00000634690
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
187 aa
20.5 kDa
No 0
EP300-007
ENSP00000488981
ENST00000634728
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
133 aa
14.7 kDa
No 0

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