Protein classes - The Human Protein Atlas

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PROTEIN CLASSES

Function and compartment based
Protein class	No of genes	No of genes with antibodies	Source
Enzymes »	3262	3048
ENZYME proteins	2979	2805	ENZYME
Oxidoreductases	393	363	ENZYME
Transferases	1267	1200	ENZYME
Hydrolases	1039	970	ENZYME
Lyases	130	123	ENZYME
Isomerase	101	100	ENZYME
Ligase	105	104	ENZYME
Peptidases	540	481	UniProt/Merops
Aspartic-type peptidases	18	17	UniProt/Merops
Cysteine-type peptidases	160	153	UniProt/Merops
Metallopeptidases	175	151	UniProt/Merops
Serine-type peptidases	167	143	UniProt/Merops
Threonine-type peptidases	20	17	UniProt/Merops
Kinases	501	481	UniProt
AGC Ser/Thr protein kinases	56	55	UniProt
Tyr protein kinases	88	85	UniProt
TKL Ser/Thr protein kinases	34	31	UniProt
STE Ser/Thr protein kinases	55	55	UniProt
RGC receptor guanylate cyclase kinases	5	2	UniProt
NEK Ser/Thr protein kinases	11	11	UniProt
CMGC Ser/Thr protein kinases	61	59	UniProt
CK1 Ser/Thr protein kinases	12	12	UniProt
CAMK Ser/Thr protein kinases	73	70	UniProt
Atypical kinases	27	26	UniProt
CD markers	374	326	UniProt
Blood group antigen proteins	31	25	UniProt
Nuclear receptors	49	43	NucleaRDB
Transporters »	1163	1005	TCDB
Transporter channels and pores	379	320	TCDB
Electrochemical Potential-driven transporters	396	348	TCDB
Primary Active Transporters	139	129	TCDB
Transport Electron Carriers	13	10	TCDB
Accessory Factors Involved in Transport	84	74	TCDB
Ribosomal proteins	149	143	UniProt
G-protein coupled receptors »	774	390	UniProt
Family 3 (C) receptors	21	17	UniProt
GPCRs excl olfactory receptors	395	280	UniProt
Adenosine and adenine nucleotide receptors	18	15	UniProt
Chemokines and chemotactic factors receptors	29	24	UniProt
Lysolipids receptors	14	11	UniProt
Odorant/olfactory and gustatory receptors	379	110	UniProt
Opsins	11	5	UniProt
Serotonin receptors	12	9	UniProt
Family 2 (B) receptors	47	39	UniProt
Family T2R receptors (taste receptor GPCRs)	24	6	UniProt
Family fz/smo receptors	11	10	UniProt
Voltage-gated ion channels »	132	100	IUPHAR-DB
Calcium-Activated Potassium Channels	7	7	IUPHAR-DB
CatSper and Two-Pore Channels	4	3	IUPHAR-DB
Cyclic Nucleotide-Regulated Channels	9	5	IUPHAR-DB
Inwardly Rectifying Potassium Channels	15	11	IUPHAR-DB
Transient Receptor Potential Channels	24	18	IUPHAR-DB
Two-P Potassium Channels	14	9	IUPHAR-DB
Voltage-Gated Calcium Channels	10	8	IUPHAR-DB
Voltage-Gated Potassium Channels	40	32	IUPHAR-DB
Voltage-Gated Sodium Channels	9	7	IUPHAR-DB
Predicted membrane proteins »	5455	4431	MDM
Prediction method-based	5455	4431	MDM
Membrane proteins predicted by MDM	5455	4431	MDM
MEMSAT3 predicted membrane proteins *	7217	5917	MEMSAT3
MEMSAT-SVM predicted membrane proteins *	6286	5138	MEMSAT-SVM
Phobius predicted membrane proteins *	5753	4677	Phobius
SCAMPI predicted membrane proteins *	6332	5253	SCAMPI
SPOCTOPUS predicted membrane proteins *	7638	6424	SPOCTOPUS
THUMBUP predicted membrane proteins *	7111	5907	THUMBUP
TMHMM predicted membrane proteins *	5503	4405	TMHMM
GPCRHMM predicted membrane proteins *	827	438	GPCRHMM
# TM segments-based	5455	4431	MDM
1TM proteins predicted by MDM	3107	2717	MDM
9TM proteins predicted by MDM	132	116	MDM
8TM proteins predicted by MDM	165	144	MDM
7TM proteins predicted by MDM	951	552	MDM
6TM proteins predicted by MDM	313	267	MDM
5TM proteins predicted by MDM	290	242	MDM
4TM proteins predicted by MDM	559	467	MDM
3TM proteins predicted by MDM	559	477	MDM
2TM proteins predicted by MDM	935	826	MDM
>9TM proteins predicted by MDM	493	435	MDM
Predicted secreted proteins »	2918	2463	HPA
Secreted proteins predicted by MDSEC	2918	2463	HPA
SignalP predicted secreted proteins *	2504	2091	SignalP
Phobius predicted secreted proteins *	3304	2821	Phobius
SPOCTOPUS predicted secreted proteins *	3705	3170	SPOCTOPUS
Predicted intracellular proteins	14889	13409	HPA
Plasma proteins	3751	3519	Plasma Proteome Database
Transcription factors »	1499	1356	UMG
Yet undefined DNA-binding domains	19	18	UMG
Basic domains	173	154	UMG
Zinc-coordinating DNA-binding domains	778	710	UMG
Helix-turn-helix domains	395	352	UMG
Other all-alpha-helical DNA-binding domains	46	42	UMG
alpha-Helices exposed by beta-structures	13	13	UMG
Immunoglobulin fold	62	55	UMG
beta-Hairpin exposed by an alpha/beta-scaffold	14	13	UMG
beta-Sheet binding to DNA	5	5	UMG
beta-Barrel DNA-binding domains	3	3	UMG
RNA polymerase related proteins	31	30	KEGG
RAS pathway related proteins	228	206	KEGG
Citric acid cycle related proteins	30	29	KEGG

Disease and drug related
Protein class	No of genes	No of genes with antibodies	Source
Cancer-related genes »	1706	1611
Candidate cancer biomarkers	1050	974	Plasma Proteome Institute
Mutated cancer genes	260	254	Publication
Mutational cancer driver genes	289	284	Publication
COSMIC somatic mutations in cancer genes	555	543	COSMIC
COSMIC Amplifications	16	15	COSMIC
COSMIC Splicing Mutations	74	73	COSMIC
COSMIC Somatic Mutations	516	506	COSMIC
COSMIC Other Mutations	35	35	COSMIC
COSMIC Nonsense Mutations	117	115	COSMIC
COSMIC Missense Mutations	198	194	COSMIC
COSMIC Large Deletions	38	38	COSMIC
COSMIC Germline Mutations	87	84	COSMIC
COSMIC Frameshift Mutations	131	128	COSMIC
COSMIC Translocations	338	330	COSMIC
Candidate cardiovascular disease genes	161	147	Plasma Proteome Institute
Disease related genes	3541	3226	UniProt
FDA approved drug targets »	646	551	Drugbank
Biotech drugs	117	95	Drugbank
Small molecule drugs	556	475	Drugbank
Potential drug targets	1129	1043	HPA

Evidence based
Protein class	No of genes	No of genes with antibodies	Source
Mapped to UniProt SWISS-PROT »	18881	16620	UniProt
UniProt - Evidence at protein level	14383	13220	UniProt
UniProt - Evidence at transcript level	3843	3021	UniProt
UniProt - Inferred from homology	542	302	UniProt
UniProt - Predicted	71	49	UniProt
UniProt - Uncertain	63	46	UniProt
Protein evidence (Kim et al 2014)	12743	11969	Kim et al 2014
Protein evidence (Ezkurdia et al 2014)	11665	11140	Ezkurdia et al 2014

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.

Function and compartment based

Disease and drug related

Evidence based