|
DICTIONARY
|
|
The aim of the dictionary is to facilitate the interpretation and use of the image-based data available in the Human Protein Atlas, but also to serve as a tool for training and understanding tissue histology, pathology and cell biology. The dictionary contains three main parts, normal tissues, cancer tissues and cells, and is based on high-resolution images at different magnifications of full tissue sections stained with hematoxylin-eosin (HE). The cell atlas is centered on immunofluorescence and confocal microscopy images, using different color channels to highlight the organelle structure of a cell.
|
|
|
|
|
| |
NORMAL TISSUE HISTOLOGY
|
|
|
CANCER HISTOLOGY
|
|
|
CELL STRUCTURE
|
|
|
PROTEIN EXPRESSION
|
|
| |
 |
|
|
 |
|
|
 |
|
|
 |
|
| |
Tissue histology overview |
|
|
Hallmarks of cancer |
|
|
Cell structure overview |
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
Immunohistochemistry
|
ACTA2
Smooth muscle marker |
AMACR
Marker for prostate cancer |
AMY1A
Amylase - Marker for salivary gland and pancreas |
CD1A
Marker for antigen presenting cells |
CD3E
CD3 - General T cell marker |
CD4
T helper cell marker |
CD55
Marker for the reticular network in lymphatic tissues |
CD68
General monocyte/histiocyte/macrophage marker |
CD79A
General B cell marker |
CD8A
CD8 - T cytotoxic cell marker |
CDH1
E-cadherin - Marker for non-neural epithelial cells |
CDX2
Marker for cells in the gastrointestinal tract |
CHGA
Chromogranin A - Marker for neuroendocrine cells |
DES
Desmin - Marker for muscle cells |
ERBB2
HER2 - Treatment predictive marker for cancer |
ESR1
Estrogen receptor alpha - Marker for female tissues and cancers |
FLG
Filaggrin - Differentiation marker for squamous epithelia |
GAST
Gastrin - Marker for G-cells of the stomach |
GCG
Glucagon - Marker for pancreatic alpha-cells |
GFAP
Glial fibrillary acidic protein - Marker for astrocytes |
INS
Insulin - Marker for pancreatic beta-cells |
KLK3
PSA - Marker for normal prostate and prostate cancer |
KRT18
Keratin 18 - Epithelial cell marker used for differential diagnostics of cancer |
KRT19
Keratin 19 - Epithelial cell marker used for differential diagnostics of cancer |
KRT20
Keratin 20 - Epithelial cell marker used for differential diagnostics of cancer |
KRT6A
Keratin 6 (KRT6) - Epithelial cell marker used for differential diagnostics of cancer |
MKI67
Ki-67 - General marker for proliferation |
MLANA
Melan-A - Marker for normal melanocytes and melanoma |
MME
CD10 - Marker for acute lymphoblastic leukemia |
NKX2-1
NK2 homeobox 1 (TTF1) - Marker for lungcancer |
PECAM1
CD31 - Marker for blood vessels |
PGR
Progesterone receptor - Marker for female tissues and cancers |
PODXL
Marker for podocytes in glomeruli |
PTH
Parathyroid hormone - Marker for the parathyroid gland |
PTPRC
CD45 - General marker for hematopoietic and immune cells. |
S100B
S100 - Marker for neurogenic and melanocytic cells |
SATB2
Marker for colorectal cancer |
SDC1
CD138 - General plasma cell marker |
SST
Somatostatin - Marker for pancreatic delta-cells |
TG
Thyroglobulin - Marker for normal thyroid and thyroid cancer |
TNNT3
Troponin T type 3 - Marker for fast skeletal muscles |
TP53
Tumor protein p53 - The anti-cancer watchdog |
TP63
P63 - Marker for basal epithelial cells |
VIM
Vimentin - Marker for mesenchymal cells |
|
|
|
|
|
| |
|
Complementary annotation dictionaries using antibodies found in the Human Protein Atlas are available as PDF-documents:
Immunohistochemistry annotation dictionary: screen usage (15MB), printing (95MB).
|
| |
|
|
