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NRG1

GENERAL INFORMATION

Gene name

 NRG1

Gene description

 Neuregulin 1

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 18
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in lymphoid tissue and CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
HPA010964
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION

Gene name

 NRG1 (HGNC Symbol)

Synonyms

 GGF, HGL, HRG, NDF, NRG1-IT2

Description

 Neuregulin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Jun 2014]

Chromosome

 8

Cytoband

 p12

Chromosome location (bp)

 31639386 - 32767959

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157168 (version 83.38)

Entrez gene

 3084

UniProt

 Q02297 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02297

Antibodypedia

 NRG1 antibodies

PROTEIN BROWSER
«
NRG1-001
NRG1-002
NRG1-003
NRG1-004
NRG1-006
NRG1-007
NRG1-008
NRG1-009
NRG1-010
NRG1-011
NRG1-012
NRG1-013
NRG1-014
NRG1-017
NRG1-018
NRG1-021
NRG1-201
NRG1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NRG1-001
ENSP00000434640
ENST00000520407
Q02297 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform Neuregulin-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003712 [transcription cofactor activity]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0007154 [cell communication]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014032 [neural crest cell development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030879 [mammary gland development]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0042060 [wound healing]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043624 [cellular protein complex disassembly]
GO:0045087 [innate immune response]
GO:0045785 [positive regulation of cell adhesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0051155 [positive regulation of striated muscle cell differentiation]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060956 [endocardial cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 422 aa
45.1 kDa 		Yes 0
NRG1-002
ENSP00000429067
ENST00000523534
H0YBA3 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0009790 [embryo development]
GO:0016021 [integral component of membrane]
GO:0035556 [intracellular signal transduction]
Show all
 713 aa
78.8 kDa 		No 1
NRG1-003
ENSP00000430120
ENST00000523079
Q02297 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform Neuregulin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003712 [transcription cofactor activity]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0007154 [cell communication]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014032 [neural crest cell development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030879 [mammary gland development]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0042060 [wound healing]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043624 [cellular protein complex disassembly]
GO:0045087 [innate immune response]
GO:0045785 [positive regulation of cell adhesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0051155 [positive regulation of striated muscle cell differentiation]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060956 [endocardial cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 420 aa
46.2 kDa 		No 1
NRG1-004
ENSP00000349275
ENST00000356819
Q02297 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform Neuregulin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003712 [transcription cofactor activity]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0007154 [cell communication]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014032 [neural crest cell development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030879 [mammary gland development]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0042060 [wound healing]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043624 [cellular protein complex disassembly]
GO:0045087 [innate immune response]
GO:0045785 [positive regulation of cell adhesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0051155 [positive regulation of striated muscle cell differentiation]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060956 [endocardial cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 637 aa
70.2 kDa 		No 1
NRG1-006
ENSP00000428828
ENST00000521670
Q02297 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform Neuregulin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003712 [transcription cofactor activity]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0007154 [cell communication]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014032 [neural crest cell development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030879 [mammary gland development]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0042060 [wound healing]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043624 [cellular protein complex disassembly]
GO:0045087 [innate immune response]
GO:0045785 [positive regulation of cell adhesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0051155 [positive regulation of striated muscle cell differentiation]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060956 [endocardial cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 462 aa
50.9 kDa 		No 1
NRG1-007
ENSP00000432052
ENST00000518206
H0YCP0 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0009790 [embryo development]
GO:0035556 [intracellular signal transduction]
Show all
 126 aa
13.1 kDa 		No 0
NRG1-008
ENSP00000429582
ENST00000519301
Q02297 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform Neuregulin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003712 [transcription cofactor activity]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0007154 [cell communication]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014032 [neural crest cell development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030879 [mammary gland development]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0042060 [wound healing]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043624 [cellular protein complex disassembly]
GO:0045087 [innate immune response]
GO:0045785 [positive regulation of cell adhesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0051155 [positive regulation of striated muscle cell differentiation]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060956 [endocardial cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 590 aa
65.5 kDa 		No 1
NRG1-009
ENSP00000430053
ENST00000518104
E7EX30 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0009790 [embryo development]
GO:0016021 [integral component of membrane]
GO:0035556 [intracellular signal transduction]
Show all
 481 aa
53.3 kDa 		No 1
NRG1-010
ENSP00000433350
ENST00000523041
H0YDC2 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005622 [intracellular]
GO:0009790 [embryo development]
GO:0016021 [integral component of membrane]
GO:0035556 [intracellular signal transduction]
Show all
 196 aa
20.8 kDa 		No 1
NRG1-011
ENSP00000433289
ENST00000520502
Q02297 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform Neuregulin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003712 [transcription cofactor activity]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0007154 [cell communication]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014032 [neural crest cell development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030879 [mammary gland development]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0042060 [wound healing]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043624 [cellular protein complex disassembly]
GO:0045087 [innate immune response]
GO:0045785 [positive regulation of cell adhesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0051155 [positive regulation of striated muscle cell differentiation]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060956 [endocardial cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 296 aa
31.7 kDa 		No 1
NRG1-012
ENSP00000428546
ENST00000518084
E5RHQ1 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0009790 [embryo development]
GO:0035556 [intracellular signal transduction]
Show all
 101 aa
11.4 kDa 		No 0
NRG1-013
ENSP00000430862
ENST00000522402
E5RHP6 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0009790 [embryo development]
GO:0016021 [integral component of membrane]
GO:0035556 [intracellular signal transduction]
Show all
 129 aa
14.5 kDa 		No 1
NRG1-014
ENSP00000428411
ENST00000519240
E5RIG8 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0009790 [embryo development]
GO:0016021 [integral component of membrane]
GO:0035556 [intracellular signal transduction]
Show all
 135 aa
15.4 kDa 		No 1
NRG1-017
ENSP00000384620
ENST00000405005
Q02297 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform Neuregulin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003712 [transcription cofactor activity]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0007154 [cell communication]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014032 [neural crest cell development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030879 [mammary gland development]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0042060 [wound healing]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043624 [cellular protein complex disassembly]
GO:0045087 [innate immune response]
GO:0045785 [positive regulation of cell adhesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0051155 [positive regulation of striated muscle cell differentiation]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060956 [endocardial cell differentiation]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 640 aa
70.4 kDa 		No 1
NRG1-018
ENSP00000486375
ENST00000631040
A0A0D9SF85 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0009790 [embryo development]
GO:0035556 [intracellular signal transduction]
Show all
 193 aa
21.1 kDa 		No 0
NRG1-021
ENSP00000287842
ENST00000287842
Q02297 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform Neuregulin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000902 [cell morphogenesis]
GO:0001964 [startle response]
GO:0003161 [cardiac conduction system development]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003712 [transcription cofactor activity]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005176 [ErbB-2 class receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007154 [cell communication]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0007420 [brain development]
GO:0007422 [peripheral nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007626 [locomotory behavior]
GO:0008083 [growth factor activity]
GO:0008217 [regulation of blood pressure]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008366 [axon ensheathment]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0009897 [external side of plasma membrane]
GO:0010001 [glial cell differentiation]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014032 [neural crest cell development]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015758 [glucose transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0016477 [cell migration]
GO:0021781 [glial cell fate commitment]
GO:0021842 [chemorepulsion involved in interneuron migration from the subpallium to the cortex]
GO:0022008 [neurogenesis]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030673 [axolemma]
GO:0030879 [mammary gland development]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031594 [neuromuscular junction]
GO:0031643 [positive regulation of myelination]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038127 [ERBB signaling pathway]
GO:0042060 [wound healing]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042552 [myelination]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043496 [regulation of protein homodimerization activity]
GO:0043497 [regulation of protein heterodimerization activity]
GO:0043624 [cellular protein complex disassembly]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045202 [synapse]
GO:0045213 [neurotransmitter receptor metabolic process]
GO:0045499 [chemorepellent activity]
GO:0045595 [regulation of cell differentiation]
GO:0045773 [positive regulation of axon extension]
GO:0045785 [positive regulation of cell adhesion]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048663 [neuron fate commitment]
GO:0048709 [oligodendrocyte differentiation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051048 [negative regulation of secretion]
GO:0051155 [positive regulation of striated muscle cell differentiation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060956 [endocardial cell differentiation]
GO:0060999 [positive regulation of dendritic spine development]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
GO:2000010 [positive regulation of protein localization to cell surface]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2001223 [negative regulation of neuron migration]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 645 aa
71.2 kDa 		No 1
NRG1-201
ENSP00000439276
ENST00000539990
F6RJN6 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0009790 [embryo development]
GO:0016021 [integral component of membrane]
GO:0035556 [intracellular signal transduction]
Show all
 308 aa
34.4 kDa 		No 1
NRG1-202
ENSP00000483727
ENST00000614767
A0A087X0X9 [Direct mapping]
Pro-neuregulin-1, membrane-bound isoform
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
Show all
 254 aa
26.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.