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UBE2L3

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GENERAL INFORMATION

Gene name

 UBE2L3

Gene description

 Ubiquitin-conjugating enzyme E2L 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA062415
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & cytosol.

Main location

 Nucleus (supported), Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA062415 A-431 Nucleus
Cytosol
HPA062415 HEK 293 Nucleoplasm
Cytosol
HPA062415 U-2 OS No staining    

GENE INFORMATION

Gene name

 UBE2L3 (HGNC Symbol)

Synonyms

 UBCH7

Description

 Ubiquitin-conjugating enzyme E2L 3 (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 21549447 - 21624034

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185651 (version 83.38)

Entrez gene

 7332

UniProt

 P68036 (UniProt - Evidence at protein level)

neXtProt

 NX_P68036

Antibodypedia

 UBE2L3 antibodies

PROTEIN BROWSER
UBE2L3-001
UBE2L3-201
UBE2L3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2L3-001
ENSP00000344259
ENST00000342192
P68036 [Direct mapping]
Ubiquitin-conjugating enzyme E2 L3
A0A024R1A4 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2L 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008283 [cell proliferation]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044770 [cell cycle phase transition]
GO:0044822 [poly(A) RNA binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0097027 [ubiquitin-protein transferase activator activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 154 aa
17.9 kDa 		No 0
UBE2L3-201
ENSP00000400906
ENST00000458578
P68036 [Direct mapping]
Ubiquitin-conjugating enzyme E2 L3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008283 [cell proliferation]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044770 [cell cycle phase transition]
GO:0044822 [poly(A) RNA binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0097027 [ubiquitin-protein transferase activator activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 212 aa
24 kDa 		No 0
UBE2L3-202
ENSP00000445931
ENST00000545681
P68036 [Direct mapping]
Ubiquitin-conjugating enzyme E2 L3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008283 [cell proliferation]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044770 [cell cycle phase transition]
GO:0044822 [poly(A) RNA binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0097027 [ubiquitin-protein transferase activator activity]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 122 aa
14.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.