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RPL10A

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GENERAL INFORMATION

Gene name

 RPL10A

Gene description

 Ribosomal protein L10a

Protein class

 Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol & endoplasmic reticulum. In addition localized to the nucleoli.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Endoplasmic reticulum (supported), Cytosol (supported)

Additional location

 In addition localized to the Nucleoli (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA053803
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol & endoplasmic reticulum. In addition localized to the nucleoli.

Main location

 Endoplasmic reticulum (supported), Cytosol (supported)

Additional location

 Nucleoli (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053803 MCF7 Nucleoli
Endoplasmic reticulum
Cytosol
HPA053803 PC-3 Nucleoli
Endoplasmic reticulum
Cytosol
HPA053803 U-2 OS Nucleoli
Endoplasmic reticulum
Cytosol

GENE INFORMATION

Gene name

 RPL10A (HGNC Symbol)

Synonyms

 Csa-19, L10A, NEDD6

Description

 Ribosomal protein L10a (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 35468408 - 35470785

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198755 (version 83.38)

Entrez gene

 4736

UniProt

 P62906 (UniProt - Evidence at protein level)

neXtProt

 NX_P62906

Antibodypedia

 RPL10A antibodies

PROTEIN BROWSER
RPL10A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPL10A-001
ENSP00000363018
ENST00000322203
P62906 [Direct mapping]
60S ribosomal protein L10a
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Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0015934 [large ribosomal subunit]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 217 aa
24.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.