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Lymphomas and cases of breast cancers showed moderate to strong cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
SASH3 (HGNC Symbol)
Synonyms
753P9, CXorf9, HACS2, SH3D6C, SLY
Description
SAM and SH3 domain containing 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling. This protein may function as a signaling adapter protein in lymphocytes.[provided by RefSeq, Sep 2009]
O75995 [Direct mapping] SAM and SH3 domain-containing protein 3
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Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002639 [positive regulation of immunoglobulin production] GO:0002726 [positive regulation of T cell cytokine production] GO:0002821 [positive regulation of adaptive immune response] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0030890 [positive regulation of B cell proliferation] GO:0032729 [positive regulation of interferon-gamma production] GO:0032733 [positive regulation of interleukin-10 production] GO:0032743 [positive regulation of interleukin-2 production] GO:0032753 [positive regulation of interleukin-4 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0042102 [positive regulation of T cell proliferation] GO:0043372 [positive regulation of CD4-positive, alpha-beta T cell differentiation] GO:0046622 [positive regulation of organ growth] GO:0048873 [homeostasis of number of cells within a tissue] GO:0051251 [positive regulation of lymphocyte activation]