Tissue expression of DPM1 - Summary - The Human Protein Atlas

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DPM1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DPM1
Gene description	Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA051818
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DPM1 (HGNC Symbol)
Synonyms	CDGIE, MPDS
Description	Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit (HGNC Symbol)
Entrez gene summary	Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Chromosome	20
Cytoband	q13.13
Chromosome location (bp)	50934867 - 50958555
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000000419 (version 83.38)
Entrez gene	8813
UniProt	O60762 (UniProt - Evidence at protein level)
neXtProt	NX_O60762
Antibodypedia	DPM1 antibodies

PROTEIN BROWSER

DPM1-001	DPM1-003	DPM1-004	DPM1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPM1-001 ENSP00000360644 ENST00000371588	O60762 [Direct mapping] Dolichol-phosphate mannosyltransferase subunit 1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004169 [dolichyl-phosphate-mannose-protein mannosyltransferase activity] GO:0004582 [dolichyl-phosphate beta-D-mannosyltransferase activity] GO:0005515 [protein binding] GO:0005537 [mannose binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019348 [dolichol metabolic process] GO:0019673 [GDP-mannose metabolic process] GO:0033185 [dolichol-phosphate-mannose synthase complex] GO:0035268 [protein mannosylation] GO:0035269 [protein O-linked mannosylation] GO:0043178 [alcohol binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	260 aa 29.6 kDa	No	0
DPM1-003 ENSP00000360640 ENST00000371584	H0Y368 [Direct mapping] Dolichol-phosphate mannosyltransferase subunit 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		295 aa 33.2 kDa	No	0
DPM1-004 ENSP00000394921 ENST00000413082	Q5QPJ9 [Direct mapping] Dolichol-phosphate mannosyltransferase subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		221 aa 25.1 kDa	No	0
DPM1-005 ENSP00000360638 ENST00000371582	Q5QPK2 [Direct mapping] Dolichol-phosphate mannosyltransferase subunit 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		287 aa 32.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.