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FGR

CANCER ATLAS

Gene description

 FGR proto-oncogene, Src family tyrosine kinase

Protein class

 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002024

GENE INFORMATION

Gene name

 FGR (HGNC Symbol)

Synonyms

 c-fgr, p55c-fgr, SRC2

Description

 FGR proto-oncogene, Src family tyrosine kinase (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p35.3

Chromosome location (bp)

 27612064 - 27635277

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000000938 (version 83.38)

Entrez gene

 2268

UniProt

 P09769 (UniProt - Evidence at protein level)

neXtProt

 NX_P09769

Antibodypedia

 FGR antibodies

PROTEIN BROWSER
FGR-001
FGR-002
FGR-004
FGR-007
FGR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGR-001
ENSP00000363117
ENST00000374005
P09769 [Direct mapping]
Tyrosine-protein kinase Fgr
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008360 [regulation of cell shape]
GO:0009615 [response to virus]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0034987 [immunoglobulin receptor binding]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell proliferation]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050764 [regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 529 aa
59.5 kDa 		No 0
FGR-002
ENSP00000363115
ENST00000374003
P09769 [Direct mapping]
Tyrosine-protein kinase Fgr
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008360 [regulation of cell shape]
GO:0009615 [response to virus]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0034987 [immunoglobulin receptor binding]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell proliferation]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050764 [regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 529 aa
59.5 kDa 		No 0
FGR-004
ENSP00000363116
ENST00000374004
P09769 [Direct mapping]
Tyrosine-protein kinase Fgr
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008360 [regulation of cell shape]
GO:0009615 [response to virus]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0034987 [immunoglobulin receptor binding]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell proliferation]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050764 [regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 529 aa
59.5 kDa 		No 0
FGR-007
ENSP00000407670
ENST00000457296
Q5TGY6 [Direct mapping]
Tyrosine-protein kinase Fgr
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 313 aa
34.7 kDa 		No 0
FGR-201
ENSP00000382126
ENST00000399173
P09769 [Direct mapping]
Tyrosine-protein kinase Fgr
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008360 [regulation of cell shape]
GO:0009615 [response to virus]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0034987 [immunoglobulin receptor binding]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell proliferation]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050764 [regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 529 aa
59.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.