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Moderate to strong cytoplasmic immunoreactivity with additional membranous and/or nuclear staining was observed in most prostate and thyroid cancers along with several ovarian cancers, hepatocellular carcinomas and a few duct carcinomas of breast. Remaining cancer tissues were weakly stained or generally negative.
GENE INFORMATION
Gene name
KLHL13 (HGNC Symbol)
Synonyms
BKLHD2, FLJ10262, KIAA1309
Description
Kelch-like family member 13 (HGNC Symbol)
Entrez gene summary
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]