Cell atlas - CYP26B1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CYP26B1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CYP26B1
Gene description	Cytochrome P450, family 26, subfamily B, polypeptide 1
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (U-2 OS, RH-30, HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA012567
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS, RH-30, HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA012567	A-431	Cytosol	Intensity
	HPA012567	U-2 OS	Cytosol
	HPA012567	U-251 MG	Cytosol	Intensity

GENE INFORMATION
Gene name	CYP26B1 (HGNC Symbol)
Synonyms	P450RAI-2
Description	Cytochrome P450, family 26, subfamily B, polypeptide 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Chromosome	2
Cytoband	p13.2
Chromosome location (bp)	72129238 - 72148038
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000003137 (version 83.38)
Entrez gene	56603
UniProt	Q9NR63 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR63
Antibodypedia	CYP26B1 antibodies

PROTEIN BROWSER

CYP26B1-001	CYP26B1-002	CYP26B1-003	CYP26B1-004	CYP26B1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP26B1-001 ENSP00000001146 ENST00000001146	Q9NR63 [Direct mapping] Cytochrome P450 26B1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001709 [cell fate determination] GO:0001972 [retinoic acid binding] GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006766 [vitamin metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007140 [male meiosis] GO:0007283 [spermatogenesis] GO:0008401 [retinoic acid 4-hydroxylase activity] GO:0009954 [proximal/distal pattern formation] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0030326 [embryonic limb morphogenesis] GO:0034653 [retinoic acid catabolic process] GO:0042573 [retinoic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0055114 [oxidation-reduction process] GO:0060349 [bone morphogenesis] Show all	512 aa 57.5 kDa	No	0
CYP26B1-002 ENSP00000401465 ENST00000412253	E7ER08 [Direct mapping] Cytochrome P450 26B1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	321 aa 36 kDa	No	0
CYP26B1-003 ENSP00000430888 ENST00000474509	E5RHM2 [Direct mapping] Cytochrome P450 26B1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	182 aa 20.6 kDa	Yes	0
CYP26B1-004 ENSP00000430871 ENST00000461519	E5RHN4 [Direct mapping] Cytochrome P450 26B1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	172 aa 19.5 kDa	Yes	0
CYP26B1-201 ENSP00000443304 ENST00000546307	Q9NR63 [Direct mapping] Cytochrome P450 26B1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001709 [cell fate determination] GO:0001972 [retinoic acid binding] GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006766 [vitamin metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007140 [male meiosis] GO:0007283 [spermatogenesis] GO:0008401 [retinoic acid 4-hydroxylase activity] GO:0009954 [proximal/distal pattern formation] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0030326 [embryonic limb morphogenesis] GO:0034653 [retinoic acid catabolic process] GO:0044281 [small molecule metabolic process] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0055114 [oxidation-reduction process] GO:0060349 [bone morphogenesis] Show all	437 aa 49 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.