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ICA1

GENERAL INFORMATION

Gene name

 ICA1

Gene description

 Islet cell autoantigen 1, 69kDa

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General mainly cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA017646
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ICA1 (HGNC Symbol)

Synonyms

 ICAp69

Description

 Islet cell autoantigen 1, 69kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Chromosome

 7

Cytoband

 p21.3

Chromosome location (bp)

 8113184 - 8262687

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000003147 (version 83.38)

Entrez gene

 3382

UniProt

 Q05084 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05084

Antibodypedia

 ICA1 antibodies

PROTEIN BROWSER
«
ICA1-001
ICA1-002
ICA1-003
ICA1-006
ICA1-007
ICA1-008
ICA1-009
ICA1-011
ICA1-012
ICA1-201
ICA1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ICA1-001
ENSP00000385570
ENST00000402384
Q05084 [Direct mapping]
Islet cell autoantigen 1
A0A024RA29 [Target identity:100%; Query identity:100%]
Islet cell autoantigen 1, 69kDa, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005795 [Golgi stack]
GO:0005829 [cytosol]
GO:0006836 [neurotransmitter transport]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030658 [transport vesicle membrane]
GO:0030667 [secretory granule membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0043496 [regulation of protein homodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050796 [regulation of insulin secretion]
Show all
 483 aa
54.6 kDa 		No 0
ICA1-002
ENSP00000265577
ENST00000265577
Q05084 [Direct mapping]
Islet cell autoantigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006836 [neurotransmitter transport]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030658 [transport vesicle membrane]
GO:0030667 [secretory granule membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0050796 [regulation of insulin secretion]
Show all
 482 aa
54.6 kDa 		No 0
ICA1-003
ENSP00000386021
ENST00000407906
E7ENI6 [Direct mapping]
Islet cell autoantigen 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0016021 [integral component of membrane]
GO:0019904 [protein domain specific binding]
GO:0030667 [secretory granule membrane]
GO:0050796 [regulation of insulin secretion]
Show all
 350 aa
41.1 kDa 		No 1
ICA1-006
ENSP00000385305
ENST00000401396
E9PDL4 [Direct mapping]
Islet cell autoantigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0019904 [protein domain specific binding]
GO:0030667 [secretory granule membrane]
GO:0050796 [regulation of insulin secretion]
Show all
 471 aa
53.2 kDa 		No 0
ICA1-007
ENSP00000379908
ENST00000396675
Q05084 [Direct mapping]
Islet cell autoantigen 1
A0A024RA29 [Target identity:100%; Query identity:100%]
Islet cell autoantigen 1, 69kDa, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006836 [neurotransmitter transport]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030658 [transport vesicle membrane]
GO:0030667 [secretory granule membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0050796 [regulation of insulin secretion]
Show all
 483 aa
54.6 kDa 		No 0
ICA1-008
ENSP00000316074
ENST00000317367
B9ZVM7 [Direct mapping]
Islet cell autoantigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0019904 [protein domain specific binding]
GO:0030667 [secretory granule membrane]
GO:0050796 [regulation of insulin secretion]
Show all
 256 aa
30.1 kDa 		No 0
ICA1-009
ENSP00000397496
ENST00000430867
C9J8Y3 [Direct mapping]
Islet cell autoantigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0019904 [protein domain specific binding]
GO:0030667 [secretory granule membrane]
GO:0050796 [regulation of insulin secretion]
Show all
 134 aa
15.5 kDa 		No 0
ICA1-011
ENSP00000398435
ENST00000447326
C9J3Y4 [Direct mapping]
Islet cell autoantigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0019904 [protein domain specific binding]
GO:0030667 [secretory granule membrane]
GO:0050796 [regulation of insulin secretion]
Show all
 162 aa
18.9 kDa 		No 0
ICA1-012
ENSP00000406722
ENST00000446305
C9IZC7 [Direct mapping]
Islet cell autoantigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0019904 [protein domain specific binding]
GO:0030667 [secretory granule membrane]
GO:0050796 [regulation of insulin secretion]
Show all
 70 aa
8.2 kDa 		No 0
ICA1-201
ENSP00000385651
ENST00000406470
Q05084 [Direct mapping]
Islet cell autoantigen 1
A0A024RA29 [Target identity:100%; Query identity:100%]
Islet cell autoantigen 1, 69kDa, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006836 [neurotransmitter transport]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030658 [transport vesicle membrane]
GO:0030667 [secretory granule membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0050796 [regulation of insulin secretion]
Show all
 483 aa
54.6 kDa 		No 0
ICA1-202
ENSP00000403982
ENST00000422063
Q05084 [Direct mapping]
Islet cell autoantigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006836 [neurotransmitter transport]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030658 [transport vesicle membrane]
GO:0030667 [secretory granule membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0050796 [regulation of insulin secretion]
Show all
 512 aa
57.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.