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CFLAR

CANCER ATLAS

Gene description

 CASP8 and FADD-like apoptosis regulator

Protein class

 Cancer-related genes, Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019044
CAB022157
CAB025216

GENE INFORMATION

Gene name

 CFLAR (HGNC Symbol)

Synonyms

 c-FLIP, CASH, CASP8AP1, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT

Description

 CASP8 and FADD-like apoptosis regulator (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 201116104 - 201176687

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000003402 (version 83.38)

Entrez gene

 8837

UniProt

 O15519 (UniProt - Evidence at protein level)

neXtProt

 NX_O15519

Antibodypedia

 CFLAR antibodies

PROTEIN BROWSER
«
CFLAR-001
CFLAR-002
CFLAR-003
CFLAR-005
CFLAR-006
CFLAR-007
CFLAR-008
CFLAR-010
CFLAR-011
CFLAR-012
CFLAR-015
CFLAR-016
CFLAR-017
CFLAR-018
CFLAR-021
CFLAR-022
CFLAR-023
CFLAR-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CFLAR-001
ENSP00000312455
ENST00000309955
O15519 [Direct mapping]
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
A0A024R3Z7 [Target identity:100%; Query identity:100%]
CASP8 and FADD-like apoptosis regulator, isoform CRA_c
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007519 [skeletal muscle tissue development]
GO:0008047 [enzyme activator activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0014732 [skeletal muscle atrophy]
GO:0014842 [regulation of satellite cell proliferation]
GO:0014866 [skeletal myofibril assembly]
GO:0016032 [viral process]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0032403 [protein complex binding]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0045121 [membrane raft]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060544 [regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1901740 [negative regulation of myoblast fusion]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 480 aa
55.3 kDa 		No 0
CFLAR-002
ENSP00000413270
ENST00000443227
O15519 [Direct mapping]
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007519 [skeletal muscle tissue development]
GO:0008047 [enzyme activator activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0014732 [skeletal muscle atrophy]
GO:0014842 [regulation of satellite cell proliferation]
GO:0014866 [skeletal myofibril assembly]
GO:0016032 [viral process]
GO:0031264 [death-inducing signaling complex]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060544 [regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1901740 [negative regulation of myoblast fusion]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 384 aa
44.1 kDa 		No 0
CFLAR-003
ENSP00000339335
ENST00000341222
O15519 [Direct mapping]
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007519 [skeletal muscle tissue development]
GO:0008047 [enzyme activator activity]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0014732 [skeletal muscle atrophy]
GO:0014842 [regulation of satellite cell proliferation]
GO:0014866 [skeletal myofibril assembly]
GO:0016032 [viral process]
GO:0031264 [death-inducing signaling complex]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060544 [regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1901740 [negative regulation of myoblast fusion]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 221 aa
25.4 kDa 		No 0
CFLAR-005
ENSP00000378580
ENST00000395148
E9PAP3 [Direct mapping]
CASP8 and FADD-like apoptosis regulator
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 250 aa
28.6 kDa 		No 0
CFLAR-006
ENSP00000345807
ENST00000341582
O15519 [Direct mapping]
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
A0A024R3Y3 [Target identity:100%; Query identity:100%]
CASP8 and FADD-like apoptosis regulator, isoform CRA_d
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007519 [skeletal muscle tissue development]
GO:0008047 [enzyme activator activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0014732 [skeletal muscle atrophy]
GO:0014842 [regulation of satellite cell proliferation]
GO:0014866 [skeletal myofibril assembly]
GO:0016032 [viral process]
GO:0031264 [death-inducing signaling complex]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060544 [regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1901740 [negative regulation of myoblast fusion]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 445 aa
51.3 kDa 		No 0
CFLAR-007
ENSP00000342809
ENST00000342795
O15519 [Direct mapping]
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007519 [skeletal muscle tissue development]
GO:0008047 [enzyme activator activity]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0014732 [skeletal muscle atrophy]
GO:0014842 [regulation of satellite cell proliferation]
GO:0014866 [skeletal myofibril assembly]
GO:0016032 [viral process]
GO:0031264 [death-inducing signaling complex]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060544 [regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1901740 [negative regulation of myoblast fusion]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 292 aa
33.3 kDa 		No 0
CFLAR-008
ENSP00000399420
ENST00000423241
O15519 [Direct mapping]
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
A0A024R3Z7 [Target identity:100%; Query identity:100%]
CASP8 and FADD-like apoptosis regulator, isoform CRA_c
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007519 [skeletal muscle tissue development]
GO:0008047 [enzyme activator activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0014732 [skeletal muscle atrophy]
GO:0014842 [regulation of satellite cell proliferation]
GO:0014866 [skeletal myofibril assembly]
GO:0016032 [viral process]
GO:0031264 [death-inducing signaling complex]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060544 [regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1901740 [negative regulation of myoblast fusion]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 480 aa
55.3 kDa 		No 0
CFLAR-010
ENSP00000406775
ENST00000440180
O15519 [Direct mapping]
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007519 [skeletal muscle tissue development]
GO:0008047 [enzyme activator activity]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0014732 [skeletal muscle atrophy]
GO:0014842 [regulation of satellite cell proliferation]
GO:0014866 [skeletal myofibril assembly]
GO:0016032 [viral process]
GO:0031264 [death-inducing signaling complex]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060544 [regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1901740 [negative regulation of myoblast fusion]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 221 aa
25.4 kDa 		No 0
CFLAR-011
ENSP00000411535
ENST00000457277
O15519 [Direct mapping]
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007519 [skeletal muscle tissue development]
GO:0008047 [enzyme activator activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0014732 [skeletal muscle atrophy]
GO:0014842 [regulation of satellite cell proliferation]
GO:0014866 [skeletal myofibril assembly]
GO:0016032 [viral process]
GO:0031264 [death-inducing signaling complex]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060544 [regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1901740 [negative regulation of myoblast fusion]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 462 aa
52.6 kDa 		No 0
CFLAR-012
ENSP00000471805
ENST00000479953
O15519 [Direct mapping]
CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007519 [skeletal muscle tissue development]
GO:0008047 [enzyme activator activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0014732 [skeletal muscle atrophy]
GO:0014842 [regulation of satellite cell proliferation]
GO:0014866 [skeletal myofibril assembly]
GO:0016032 [viral process]
GO:0031264 [death-inducing signaling complex]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060544 [regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1901740 [negative regulation of myoblast fusion]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 366 aa
41.3 kDa 		No 0
CFLAR-015
ENSP00000411897
ENST00000441224
C9J408 [Direct mapping]
CASP8 and FADD-like apoptosis regulator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 129 aa
15 kDa 		No 0
CFLAR-016
ENSP00000391029
ENST00000433445
C9J4Q0 [Direct mapping]
CASP8 and FADD-like apoptosis regulator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 64 aa
7.4 kDa 		No 0
CFLAR-017
ENSP00000409570
ENST00000425030
C9JSU3 [Direct mapping]
CASP8 and FADD-like apoptosis regulator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 62 aa
7.1 kDa 		No 0
CFLAR-018
ENSP00000412882
ENST00000417748
C9JV51 [Direct mapping]
CASP8 and FADD-like apoptosis regulator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 118 aa
13.7 kDa 		No 0
CFLAR-021
ENSP00000469608
ENST00000494258
M0QY57 [Direct mapping]
CASP8 and FADD-like apoptosis regulator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 117 aa
13.2 kDa 		No 0
CFLAR-022
ENSP00000471749
ENST00000470178
M0R1A8 [Direct mapping]
CASP8 and FADD-like apoptosis regulator
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
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 117 aa
13.3 kDa 		No 0
CFLAR-023
ENSP00000469917
ENST00000462763
M0QYM0 [Direct mapping]
CASP8 and FADD-like apoptosis regulator
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
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 168 aa
19.1 kDa 		No 0
CFLAR-201
ENSP00000339326
ENST00000340870
A0A0A0MR92 [Direct mapping]
CASP8 and FADD-like apoptosis regulator
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
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 321 aa
36.5 kDa 		No 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.