Cell atlas - RBM5 - The Human Protein Atlas

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RBM5

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RBM5
Gene description	RNA binding motif protein 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA017335 , HPA018011
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017335	A-431	Nucleoplasm
	HPA017335	U-2 OS	Nucleoplasm
	HPA017335	U-251 MG	Nucleoplasm
	HPA018011	A-431	Nucleoplasm
	HPA018011	U-2 OS	Nucleoplasm
	HPA018011	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	RBM5 (HGNC Symbol)
Synonyms	H37, LUCA15
Description	RNA binding motif protein 5 (HGNC Symbol)
Entrez gene summary	This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	50088908 - 50119021
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000003756 (version 83.38)
Entrez gene	10181
UniProt	P52756 (UniProt - Evidence at protein level)
neXtProt	NX_P52756
Antibodypedia	RBM5 antibodies

PROTEIN BROWSER

RBM5-001	RBM5-003	RBM5-007	RBM5-008	RBM5-009	RBM5-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBM5-001 ENSP00000343054 ENST00000347869	P52756 [Direct mapping] RNA-binding protein 5 A0A024R2U6 [Target identity:100%; Query identity:100%] RNA binding motif protein 5, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000245 [spliceosomal complex assembly] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0006396 [RNA processing] GO:0006915 [apoptotic process] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0043065 [positive regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	815 aa 92.2 kDa	No	0
RBM5-003 ENSP00000419534 ENST00000469838	P52756 [Direct mapping] RNA-binding protein 5 E1CJT4 [Target identity:100%; Query identity:100%] RNA-binding protein 5 variant Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000245 [spliceosomal complex assembly] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000398 [mRNA splicing, via spliceosome] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0006396 [RNA processing] GO:0006915 [apoptotic process] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0043065 [positive regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] Show all	143 aa 17.1 kDa	No	0
RBM5-007 ENSP00000390711 ENST00000441305	C9JFQ5 [Direct mapping] RNA-binding protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005654 [nucleoplasm] Show all	137 aa 16.4 kDa	No	0
RBM5-008 ENSP00000394622 ENST00000437500	C9JR02 [Direct mapping] RNA-binding protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 12.8 kDa	No	0
RBM5-009 ENSP00000406119 ENST00000417905	C9J9P7 [Direct mapping] RNA-binding protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] Show all	120 aa 14.5 kDa	No	0
RBM5-012 ENSP00000384872 ENST00000404526	F8W910 [Direct mapping] RNA-binding protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 16.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.