Expression of CAMKK1 in cancer - Summary

CANCER ATLAS

Gene description

Calcium/calmodulin-dependent protein kinase kinase 1, alpha

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Skin cancer

STAINING SUMMARY

CAB009111

GENE INFORMATION
Gene name	CAMKK1 (HGNC Symbol)
Synonyms	CAMKKA, DKFZp761M0423, MGC34095
Description	Calcium/calmodulin-dependent protein kinase kinase 1, alpha (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	3860315 - 3894891
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000004660 (version 83.38)
Entrez gene	84254
UniProt	Q8N5S9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N5S9
Antibodypedia	CAMKK1 antibodies

PROTEIN BROWSER

CAMKK1-001	CAMKK1-002	CAMKK1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAMKK1-001 ENSP00000371188 ENST00000381769	J3KPJ3 [Direct mapping] Calcium/calmodulin-dependent protein kinase kinase 1 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	532 aa 58.9 kDa	No	0
CAMKK1-002 ENSP00000158166 ENST00000158166	Q8N5S9 [Direct mapping] Calcium/calmodulin-dependent protein kinase kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007268 [synaptic transmission] GO:0032147 [activation of protein kinase activity] GO:0045860 [positive regulation of protein kinase activity] Show all	520 aa 57.5 kDa	No	0
CAMKK1-003 ENSP00000323118 ENST00000348335	Q8N5S9 [Direct mapping] Calcium/calmodulin-dependent protein kinase kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007268 [synaptic transmission] Show all	505 aa 55.7 kDa	No	0