Cell atlas - RECQL - The Human Protein Atlas

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RECQL

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RECQL
Gene description	RecQ helicase-like
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. CAB009743 , HPA030960 , HPA064259
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030960	A-431	Nucleoplasm
	HPA030960	U-2 OS	Nucleoplasm
	HPA030960	U-251 MG	Nucleoplasm
	HPA064259	RH-30	Nucleus
	HPA064259	U-2 OS	No staining
	HPA064259	U-251 MG	Nucleoplasm
	CAB009743	A-431	Nucleoplasm
	CAB009743	U-2 OS	Nucleoplasm
	CAB009743	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	RECQL (HGNC Symbol)
Synonyms	RecQ1, RecQL1
Description	RecQ helicase-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5' and 3' UTRs, have been described. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	21468911 - 21501669
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000004700 (version 83.38)
Entrez gene	5965
UniProt	P46063 (UniProt - Evidence at protein level)
neXtProt	NX_P46063
Antibodypedia	RECQL antibodies

PROTEIN BROWSER

RECQL-001	RECQL-002	RECQL-003	RECQL-004	RECQL-005	RECQL-006	RECQL-007	RECQL-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RECQL-001 ENSP00000416739 ENST00000444129	P46063 [Direct mapping] ATP-dependent DNA helicase Q1 A0A024RAV2 [Target identity:100%; Query identity:100%] RecQ protein-like (DNA helicase Q1-like), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000733 [DNA strand renaturation] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003678 [DNA helicase activity] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006310 [DNA recombination] GO:0008026 [ATP-dependent helicase activity] GO:0016020 [membrane] GO:0032508 [DNA duplex unwinding] GO:0036310 [annealing helicase activity] GO:0043140 [ATP-dependent 3'-5' DNA helicase activity] Show all	649 aa 73.5 kDa	No	0
RECQL-002 ENSP00000395449 ENST00000421138	P46063 [Direct mapping] ATP-dependent DNA helicase Q1 A0A024RAV2 [Target identity:100%; Query identity:100%] RecQ protein-like (DNA helicase Q1-like), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000733 [DNA strand renaturation] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003678 [DNA helicase activity] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006310 [DNA recombination] GO:0008026 [ATP-dependent helicase activity] GO:0016020 [membrane] GO:0032508 [DNA duplex unwinding] GO:0036310 [annealing helicase activity] GO:0043140 [ATP-dependent 3'-5' DNA helicase activity] Show all	649 aa 73.5 kDa	No	0
RECQL-003 ENSP00000440700 ENST00000539672	F5GYB7 [Direct mapping] ATP-dependent DNA helicase Q1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 8.1 kDa	No	0
RECQL-004 ENSP00000445555 ENST00000542432	F5H2L2 [Direct mapping] ATP-dependent DNA helicase Q1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] Show all	131 aa 14.6 kDa	No	0
RECQL-005 ENSP00000318727 ENST00000314748	F8WA66 [Direct mapping] ATP-dependent DNA helicase Q1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] Show all	199 aa 22.2 kDa	No	0
RECQL-006 ENSP00000439069 ENST00000536240	F5H3W0 [Direct mapping] ATP-dependent DNA helicase Q1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 12 kDa	No	0
RECQL-007 ENSP00000379400 ENST00000396093	F8WD97 [Direct mapping] ATP-dependent DNA helicase Q1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] Show all	211 aa 23.7 kDa	No	0
RECQL-008 ENSP00000446036 ENST00000536964	F5H4P4 [Direct mapping] ATP-dependent DNA helicase Q1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 11.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.