Expression of CALCR in cancer - Summary

CANCER ATLAS

Gene description

Calcitonin receptor

Protein class

Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028962

GENE INFORMATION
Gene name	CALCR (HGNC Symbol)
Synonyms	CTR
Description	Calcitonin receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Chromosome	7
Cytoband	q21.3
Chromosome location (bp)	93424487 - 93574730
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000004948 (version 83.38)
Entrez gene	799
UniProt
neXtProt
Antibodypedia	CALCR antibodies

PROTEIN BROWSER

CALCR-001	CALCR-002	CALCR-005	CALCR-201	CALCR-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CALCR-001 ENSP00000399552 ENST00000421592	A0A0A0MSQ7 [Direct mapping] Calcitonin receptor; Calcitonin receptor, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004948 [calcitonin receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	490 aa 57.3 kDa	Yes	7
CALCR-002 ENSP00000377959 ENST00000394441	A0A0C4DG16 [Direct mapping] Calcitonin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004948 [calcitonin receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	474 aa 55.3 kDa	Yes	7
CALCR-005 ENSP00000389295 ENST00000426151	A0A0C4DG16 [Direct mapping] Calcitonin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004948 [calcitonin receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	474 aa 55.3 kDa	Yes	7
CALCR-201 ENSP00000352561 ENST00000359558	A0A0A0MRG0 [Direct mapping] Calcitonin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001669 [acrosomal vesicle] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005929 [cilium] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030279 [negative regulation of ossification] GO:0030316 [osteoclast differentiation] GO:0043488 [regulation of mRNA stability] Show all	508 aa 59.4 kDa	Yes	7
CALCR-202 ENSP00000353385 ENST00000360249	D8MIV0 [Direct mapping] Calcitonin receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004948 [calcitonin receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] Show all	162 aa 19.1 kDa	Yes	0