Cell atlas - PRSS22 - The Human Protein Atlas

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PRSS22

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PRSS22
Gene description	Protease, serine, 22
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (CAPAN-2, SK-BR-3, MCF7)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049161
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, SK-BR-3, MCF7) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049161	CACO-2	Nucleoplasm
	HPA049161	MCF7	Nucleoplasm

GENE INFORMATION
Gene name	PRSS22 (HGNC Symbol)
Synonyms	BSSP-4, hBSSP-4, SP001LA
Description	Protease, serine, 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2852727 - 2858170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005001 (version 83.38)
Entrez gene	64063
UniProt	Q9GZN4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZN4
Antibodypedia	PRSS22 antibodies

PROTEIN BROWSER

PRSS22-001	PRSS22-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS22-001 ENSP00000161006 ENST00000161006	Q9GZN4 [Direct mapping] Brain-specific serine protease 4 Show all	Enzymes Peptidases Serine-type peptidases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	317 aa 33.7 kDa	Yes	0
PRSS22-002 ENSP00000458506 ENST00000571228	I3L116 [Direct mapping] Brain-specific serine protease 4 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	207 aa 21.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.