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LIG3

CANCER ATLAS

Gene description

 Ligase III, DNA, ATP-dependent

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006723

Tissue

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Tumor cells generally displayed moderate to strong nuclear positivity in a majority of cases. Most renal, cervical and endometrial cancers as well as a fraction of cases in several other malignancies were weakly stained or negative.

GENE INFORMATION

Gene name

 LIG3 (HGNC Symbol)

Synonyms

 LIG2

Description

 Ligase III, DNA, ATP-dependent (HGNC Symbol)

Entrez gene summary

 This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 34980494 - 35009743

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000005156 (version 83.38)

Entrez gene

 3980

UniProt

 P49916 (UniProt - Evidence at protein level)

neXtProt

 NX_P49916

Antibodypedia

 LIG3 antibodies

PROTEIN BROWSER
LIG3-001
LIG3-002
LIG3-005
LIG3-006
LIG3-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIG3-001
ENSP00000367787
ENST00000378526
P49916 [Direct mapping]
DNA ligase 3
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000794 [condensed nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006266 [DNA ligation]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006288 [base-excision repair, DNA ligation]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0007005 [mitochondrion organization]
GO:0007049 [cell cycle]
GO:0008270 [zinc ion binding]
GO:0043504 [mitochondrial DNA repair]
GO:0045910 [negative regulation of DNA recombination]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051301 [cell division]
GO:0070421 [DNA ligase III-XRCC1 complex]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071897 [DNA biosynthetic process]
GO:0090298 [negative regulation of mitochondrial DNA replication]
GO:0097681 [double-strand break repair via alternative nonhomologous end joining]
Show all
 1009 aa
112.9 kDa 		No 0
LIG3-002
ENSP00000262327
ENST00000262327
P49916 [Direct mapping]
DNA ligase 3
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006266 [DNA ligation]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006288 [base-excision repair, DNA ligation]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0007005 [mitochondrion organization]
GO:0007049 [cell cycle]
GO:0008270 [zinc ion binding]
GO:0043504 [mitochondrial DNA repair]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051301 [cell division]
GO:0070421 [DNA ligase III-XRCC1 complex]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071897 [DNA biosynthetic process]
GO:0090298 [negative regulation of mitochondrial DNA replication]
GO:0097681 [double-strand break repair via alternative nonhomologous end joining]
Show all
 949 aa
106 kDa 		No 0
LIG3-005
ENSP00000468479
ENST00000585941
K7ERZ5 [Direct mapping]
DNA ligase 3
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0008270 [zinc ion binding]
GO:0051103 [DNA ligation involved in DNA repair]
Show all
 545 aa
61.7 kDa 		No 0
LIG3-006
ENSP00000467063
ENST00000592690
K7ENR9 [Direct mapping]
DNA ligase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
Show all
 207 aa
23 kDa 		No 0
LIG3-007
ENSP00000467757
ENST00000585740
K7EQB6 [Direct mapping]
DNA ligase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006266 [DNA ligation]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
Show all
 185 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.