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Tumour cells generally showed moderate to strong nuclear positivity. Most cases of endometrial and gastric cancer were weakly stained or negative.
GENE INFORMATION
Gene name
CREBBP (HGNC Symbol)
Synonyms
CBP, KAT3A, RSTS, RTS
Description
CREB binding protein (HGNC Symbol)
Entrez gene summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000123 [histone acetyltransferase complex] GO:0000790 [nuclear chromatin] GO:0000940 [condensed chromosome outer kinetochore] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001666 [response to hypoxia] GO:0002039 [p53 binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006461 [protein complex assembly] GO:0006473 [protein acetylation] GO:0007165 [signal transduction] GO:0007219 [Notch signaling pathway] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0008589 [regulation of smoothened signaling pathway] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016407 [acetyltransferase activity] GO:0016573 [histone acetylation] GO:0016604 [nuclear body] GO:0018076 [N-terminal peptidyl-lysine acetylation] GO:0030718 [germ-line stem cell population maintenance] GO:0032481 [positive regulation of type I interferon production] GO:0033613 [activating transcription factor binding] GO:0034605 [cellular response to heat] GO:0034644 [cellular response to UV] GO:0042592 [homeostatic process] GO:0042733 [embryonic digit morphogenesis] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043234 [protein complex] GO:0043426 [MRF binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0048511 [rhythmic process] GO:0060355 [positive regulation of cell adhesion molecule production] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070555 [response to interleukin-1] GO:0071456 [cellular response to hypoxia] GO:0090575 [RNA polymerase II transcription factor complex] GO:0098609 [cell-cell adhesion] GO:1900034 [regulation of cellular response to heat] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000123 [histone acetyltransferase complex] GO:0000790 [nuclear chromatin] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding] GO:0001666 [response to hypoxia] GO:0002039 [p53 binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006461 [protein complex assembly] GO:0006473 [protein acetylation] GO:0007165 [signal transduction] GO:0007219 [Notch signaling pathway] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008589 [regulation of smoothened signaling pathway] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016407 [acetyltransferase activity] GO:0016573 [histone acetylation] GO:0016604 [nuclear body] GO:0018076 [N-terminal peptidyl-lysine acetylation] GO:0032481 [positive regulation of type I interferon production] GO:0034605 [cellular response to heat] GO:0034644 [cellular response to UV] GO:0042592 [homeostatic process] GO:0042733 [embryonic digit morphogenesis] GO:0043426 [MRF binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048511 [rhythmic process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] GO:1900034 [regulation of cellular response to heat]