Cell atlas - GCFC2 - The Human Protein Atlas

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GCFC2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GCFC2
Gene description	GC-rich sequence DNA-binding factor 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA077882
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA077882	SH-SY5Y	Nucleoplasm
	HPA077882	U-2 OS	Nucleoplasm
	HPA077882	U-2 OS	Cytosol

GENE INFORMATION
Gene name	GCFC2 (HGNC Symbol)
Synonyms	C2orf3, DNABF, GCF, TCF9
Description	GC-rich sequence DNA-binding factor 2 (HGNC Symbol)
Entrez gene summary	The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p12
Chromosome location (bp)	75652000 - 75710989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005436 (version 83.38)
Entrez gene	6936
UniProt	P16383 (UniProt - Evidence at protein level)
neXtProt	NX_P16383
Antibodypedia	GCFC2 antibodies

PROTEIN BROWSER

GCFC2-001	GCFC2-003	GCFC2-004	GCFC2-007	GCFC2-008	GCFC2-010	GCFC2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCFC2-001 ENSP00000318690 ENST00000321027	P16383 [Direct mapping] GC-rich sequence DNA-binding factor 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000245 [spliceosomal complex assembly] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0071008 [U2-type post-mRNA release spliceosomal complex] Show all	781 aa 89.4 kDa	No	0
GCFC2-003 ENSP00000474481 ENST00000470503	P16383 [Direct mapping] GC-rich sequence DNA-binding factor 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000245 [spliceosomal complex assembly] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0071008 [U2-type post-mRNA release spliceosomal complex] Show all	215 aa 23.6 kDa	No	0
GCFC2-004 ENSP00000386552 ENST00000409857	P16383 [Direct mapping] GC-rich sequence DNA-binding factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000245 [spliceosomal complex assembly] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0071008 [U2-type post-mRNA release spliceosomal complex] Show all	743 aa 84.8 kDa	No	0
GCFC2-007 ENSP00000415831 ENST00000442309	C9JII4 [Direct mapping] GC-rich sequence DNA-binding factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	185 aa 20.1 kDa	No	0
GCFC2-008 ENSP00000409340 ENST00000427862	H7C335 [Direct mapping] GC-rich sequence DNA-binding factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	199 aa 22.8 kDa	No	0
GCFC2-010 ENSP00000475108 ENST00000492826	S4R461 [Direct mapping] GC-rich sequence DNA-binding factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		27 aa 2.8 kDa	No	0
GCFC2-201 ENSP00000437767 ENST00000541687	P16383 [Direct mapping] GC-rich sequence DNA-binding factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000245 [spliceosomal complex assembly] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0071008 [U2-type post-mRNA release spliceosomal complex] Show all	254 aa 28 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.