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PDK2

CANCER ATLAS

Gene description

 Pyruvate dehydrogenase kinase, isozyme 2

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008287

GENE INFORMATION

Gene name

 PDK2 (HGNC Symbol)

Synonyms

 PDHK2

Description

 Pyruvate dehydrogenase kinase, isozyme 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 17

Cytoband

 q21.33

Chromosome location (bp)

 50094737 - 50112152

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000005882 (version 83.38)

Entrez gene

 5164

UniProt

 Q15119 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15119

Antibodypedia

 PDK2 antibodies

PROTEIN BROWSER
PDK2-001
PDK2-003
PDK2-008
PDK2-009
PDK2-012
PDK2-014
PDK2-016
PDK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDK2-001
ENSP00000420927
ENST00000503176
Q15119 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005967 [mitochondrial pyruvate dehydrogenase complex]
GO:0006006 [glucose metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006111 [regulation of gluconeogenesis]
GO:0006468 [protein phosphorylation]
GO:0006885 [regulation of pH]
GO:0008286 [insulin receptor signaling pathway]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0010565 [regulation of cellular ketone metabolic process]
GO:0010906 [regulation of glucose metabolic process]
GO:0031670 [cellular response to nutrient]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
Show all
 407 aa
46.2 kDa 		No 0
PDK2-003
ENSP00000007708
ENST00000007708
Q15119 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005967 [mitochondrial pyruvate dehydrogenase complex]
GO:0006006 [glucose metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006111 [regulation of gluconeogenesis]
GO:0006468 [protein phosphorylation]
GO:0006885 [regulation of pH]
GO:0008286 [insulin receptor signaling pathway]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0010565 [regulation of cellular ketone metabolic process]
GO:0010906 [regulation of glucose metabolic process]
GO:0031670 [cellular response to nutrient]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
Show all
 343 aa
38.9 kDa 		No 0
PDK2-008
ENSP00000427682
ENST00000508030
D6RHG2 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
Show all
 129 aa
14.9 kDa 		No 0
PDK2-009
ENSP00000425265
ENST00000503614
D6RDN9 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
Show all
 259 aa
29.4 kDa 		No 0
PDK2-012
ENSP00000425615
ENST00000505440
D6RJH7 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
Show all
 141 aa
16.2 kDa 		No 0
PDK2-014
ENSP00000421178
ENST00000512238
D6RGV8 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 98 aa
11.5 kDa 		No 0
PDK2-016
ENSP00000423310
ENST00000510219
D6R983 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 160 aa
18.6 kDa 		No 0
PDK2-201
ENSP00000481915
ENST00000614357
Q15119 [Direct mapping]
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005967 [mitochondrial pyruvate dehydrogenase complex]
GO:0006006 [glucose metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006111 [regulation of gluconeogenesis]
GO:0006468 [protein phosphorylation]
GO:0006885 [regulation of pH]
GO:0008286 [insulin receptor signaling pathway]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0010565 [regulation of cellular ketone metabolic process]
GO:0010906 [regulation of glucose metabolic process]
GO:0031670 [cellular response to nutrient]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
Show all
 343 aa
38.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.