Expression of LAMP2 in cancer - Summary

CANCER ATLAS

Gene description

Lysosomal-associated membrane protein 2

Protein class

CD markers, Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029100	CAB005272

GENE INFORMATION
Gene name	LAMP2 (HGNC Symbol)
Synonyms	CD107b
Description	Lysosomal-associated membrane protein 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q24
Chromosome location (bp)	120427827 - 120469365
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005893 (version 83.38)
Entrez gene	3920
UniProt	P13473 (UniProt - Evidence at protein level)
neXtProt	NX_P13473
Antibodypedia	LAMP2 antibodies

PROTEIN BROWSER

LAMP2-001	LAMP2-002	LAMP2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAMP2-001 ENSP00000200639 ENST00000200639	P13473 [Direct mapping] Lysosome-associated membrane glycoprotein 2 Show all	CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031902 [late endosome membrane] GO:0050821 [protein stabilization] GO:0061684 [chaperone-mediated autophagy] GO:0070062 [extracellular exosome] Show all	410 aa 45 kDa	Yes	1
LAMP2-002 ENSP00000360386 ENST00000371335	P13473 [Direct mapping] Lysosome-associated membrane glycoprotein 2 Show all	CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031902 [late endosome membrane] GO:0050821 [protein stabilization] GO:0061684 [chaperone-mediated autophagy] GO:0070062 [extracellular exosome] Show all	410 aa 45 kDa	Yes	1
LAMP2-004 ENSP00000408411 ENST00000434600	P13473 [Direct mapping] Lysosome-associated membrane glycoprotein 2 Show all	CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030168 [platelet activation] GO:0030670 [phagocytic vesicle membrane] GO:0031088 [platelet dense granule membrane] GO:0031902 [late endosome membrane] GO:0050821 [protein stabilization] GO:0061684 [chaperone-mediated autophagy] GO:0070062 [extracellular exosome] Show all	411 aa 45.2 kDa	Yes	1