Cell atlas - CRLF1 - The Human Protein Atlas

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CRLF1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CRLF1
Gene description	Cytokine receptor-like factor 1
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (Hep G2, EFO-21)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Hep G2, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CRLF1 (HGNC Symbol)
Synonyms	CISS, CISS1, CLF, CLF-1
Description	Cytokine receptor-like factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18572220 - 18607741
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006016 (version 83.38)
Entrez gene	9244
UniProt	O75462 (UniProt - Evidence at protein level)
neXtProt	NX_O75462
Antibodypedia	CRLF1 antibodies

PROTEIN BROWSER

CRLF1-001	CRLF1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRLF1-001 ENSP00000376188 ENST00000392386	O75462 [Direct mapping] Cytokine receptor-like factor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001657 [ureteric bud development] GO:0004872 [receptor activity] GO:0005125 [cytokine activity] GO:0005127 [ciliary neurotrophic factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0008284 [positive regulation of cell proliferation] GO:0019955 [cytokine binding] GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein] GO:0043524 [negative regulation of neuron apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0097058 [CRLF-CLCF1 complex] GO:2000672 [negative regulation of motor neuron apoptotic process] Show all	422 aa 46.3 kDa	Yes	0
CRLF1-003 ENSP00000470625 ENST00000597131	M0QZL6 [Direct mapping] Cytokine receptor-like factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	173 aa 19 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.