Expression of TNFRSF12A in cancer - Summary

CANCER ATLAS

Gene description

Tumor necrosis factor receptor superfamily, member 12A

Protein class

Cancer-related genes, CD markers, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA007853

GENE INFORMATION
Gene name	TNFRSF12A (HGNC Symbol)
Synonyms	CD266, FN14, TweakR
Description	Tumor necrosis factor receptor superfamily, member 12A (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	3018445 - 3022383
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006327 (version 83.38)
Entrez gene	51330
UniProt	Q9NP84 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP84
Antibodypedia	TNFRSF12A antibodies

PROTEIN BROWSER

TNFRSF12A-001	TNFRSF12A-002	TNFRSF12A-003	TNFRSF12A-005	TNFRSF12A-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNFRSF12A-001 ENSP00000326737 ENST00000326577	Q9NP84 [Direct mapping] Tumor necrosis factor receptor superfamily member 12A Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001726 [ruffle] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006931 [substrate-dependent cell migration, cell attachment to substrate] GO:0007155 [cell adhesion] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0043065 [positive regulation of apoptotic process] GO:0045765 [regulation of angiogenesis] GO:0045773 [positive regulation of axon extension] GO:0061041 [regulation of wound healing] GO:0097191 [extrinsic apoptotic signaling pathway] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	129 aa 13.9 kDa	Yes	1
TNFRSF12A-002 ENSP00000343894 ENST00000341627	Q9NP84 [Direct mapping] Tumor necrosis factor receptor superfamily member 12A Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0043065 [positive regulation of apoptotic process] GO:0061041 [regulation of wound healing] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	94 aa 10.2 kDa	Yes	1
TNFRSF12A-003 ENSP00000460610 ENST00000575124	I3L3P4 [Direct mapping] Tumor necrosis factor receptor superfamily member 12A Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		226 aa 24.1 kDa	Yes	0
TNFRSF12A-005 ENSP00000458898 ENST00000573001	I3L1J9 [Direct mapping] Tumor necrosis factor receptor superfamily member 12A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	80 aa 8.7 kDa	No	1
TNFRSF12A-007 ENSP00000461756 ENST00000575836	I3L539 [Direct mapping] Tumor necrosis factor receptor superfamily member 12A Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		47 aa 5.2 kDa	Yes	0