Tissue expression of DLX6 - Summary - The Human Protein Atlas

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DLX6

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DLX6
Gene description	Distal-less homeobox 6
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis, endometrium, placenta)
GTEx:	Group enriched (caudate, testis, hypothalamus)
FANTOM5:	Tissue enhanced (caudate, placenta)

Protein evidence

Evidence at transcript level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA030608
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, endometrium, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, testis, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, placenta)

GENE INFORMATION
Gene name	DLX6
Synonyms
Description	Distal-less homeobox 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q21.3
Chromosome location (bp)	97005548 - 97011039
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000006377 (version 83.38)
Entrez gene	1750
UniProt	P56179 (UniProt - Evidence at transcript level)
neXtProt	NX_P56179
Antibodypedia	DLX6 antibodies

PROTEIN BROWSER

DLX6-001	DLX6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DLX6-001 ENSP00000428480 ENST00000518156	P56179 [Direct mapping] Homeobox protein DLX-6 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001501 [skeletal system development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007399 [nervous system development] GO:0030326 [embryonic limb morphogenesis] GO:0030855 [epithelial cell differentiation] GO:0042472 [inner ear morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0060021 [palate development] GO:0060322 [head development] Show all	293 aa 32.6 kDa	No	0
DLX6-003 ENSP00000451635 ENST00000555308	G3V471 [Direct mapping] Homeobox protein DLX-6 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	165 aa 18.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.