Cell atlas - IFRD1 - The Human Protein Atlas

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IFRD1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	IFRD1
Gene description	Interferon-related developmental regulator 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA024122
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024122	A-431	Cytosol
	HPA024122	U-2 OS	Plasma membrane	Intensity
	HPA024122	U-2 OS	Cytosol	Intensity
	HPA024122	U-251 MG	Plasma membrane
	HPA024122	U-251 MG	Cytosol

GENE INFORMATION
Gene name	IFRD1 (HGNC Symbol)
Synonyms	PC4, TIS7
Description	Interferon-related developmental regulator 1 (HGNC Symbol)
Entrez gene summary	This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Chromosome	7
Cytoband	q31.1
Chromosome location (bp)	112422968 - 112481017
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006652 (version 83.38)
Entrez gene	3475
UniProt	O00458 (UniProt - Evidence at protein level)
neXtProt	NX_O00458
Antibodypedia	IFRD1 antibodies

PROTEIN BROWSER

IFRD1-001	IFRD1-002	IFRD1-003	IFRD1-005	IFRD1-006	IFRD1-007	IFRD1-008	IFRD1-009	IFRD1-011	IFRD1-013	IFRD1-014	IFRD1-201	IFRD1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFRD1-001 ENSP00000005558 ENST00000005558	O00458 [Direct mapping] Interferon-related developmental regulator 1 A4D0U1 [Target identity:100%; Query identity:100%] Interferon-related developmental regulator 1; Interferon-related developmental regulator 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0007518 [myoblast fate determination] Show all	451 aa 50.3 kDa	No	1
IFRD1-002 ENSP00000384477 ENST00000403825	O00458 [Direct mapping] Interferon-related developmental regulator 1 A4D0U1 [Target identity:100%; Query identity:100%] Interferon-related developmental regulator 1; Interferon-related developmental regulator 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007518 [myoblast fate determination] GO:0014706 [striated muscle tissue development] GO:0030517 [negative regulation of axon extension] GO:0042692 [muscle cell differentiation] GO:0043403 [skeletal muscle tissue regeneration] GO:0048671 [negative regulation of collateral sprouting] Show all	451 aa 50.3 kDa	No	1
IFRD1-003 ENSP00000397314 ENST00000429071	C9JA65 [Direct mapping] Interferon-related developmental regulator 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 15.9 kDa	No	0
IFRD1-005 ENSP00000397592 ENST00000443101	C9J7U6 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.4 kDa	No	0
IFRD1-006 ENSP00000402453 ENST00000445335	C9JLG5 [Direct mapping] Interferon-related developmental regulator 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 6.2 kDa	No	0
IFRD1-007 ENSP00000413893 ENST00000417662	C9JK78 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		18 aa 1.9 kDa	No	0
IFRD1-008 ENSP00000437250 ENST00000476927	E9PMY4 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.3 kDa	No	0
IFRD1-009 ENSP00000402177 ENST00000440625	C9JNM6 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 13.9 kDa	No	0
IFRD1-011 ENSP00000403203 ENST00000421296	C9JFH1 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.4 kDa	No	0
IFRD1-013 ENSP00000435635 ENST00000462155	H0YEE3 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 11.4 kDa	No	0
IFRD1-014 ENSP00000391379 ENST00000432734	C9J311 [Direct mapping] Interferon-related developmental regulator 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 2.9 kDa	No	0
IFRD1-201 ENSP00000439188 ENST00000535603	O00458 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0007518 [myoblast fate determination] Show all	401 aa 45.3 kDa	No	1
IFRD1-202 ENSP00000483255 ENST00000621379	O00458 [Direct mapping] Interferon-related developmental regulator 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0007518 [myoblast fate determination] Show all	401 aa 45.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.