Expression of COX10 in cancer - Summary

CANCER ATLAS

Gene description

COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA032005	HPA032006

GENE INFORMATION
Gene name	COX10
Synonyms
Description	COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor (HGNC Symbol)
Entrez gene summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p12
Chromosome location (bp)	14069496 - 14208677
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006695 (version 83.38)
Entrez gene	1352
UniProt	Q12887 (UniProt - Evidence at protein level)
neXtProt	NX_Q12887
Antibodypedia	COX10 antibodies

PROTEIN BROWSER

COX10-001	COX10-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX10-001 ENSP00000261643 ENST00000261643	Q12887 [Direct mapping] Protoheme IX farnesyltransferase, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000266 [mitochondrial fission] GO:0004129 [cytochrome-c oxidase activity] GO:0004311 [farnesyltranstransferase activity] GO:0004659 [prenyltransferase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen] GO:0006778 [porphyrin-containing compound metabolic process] GO:0006783 [heme biosynthetic process] GO:0006784 [heme a biosynthetic process] GO:0007005 [mitochondrion organization] GO:0008495 [protoheme IX farnesyltransferase activity] GO:0008535 [respiratory chain complex IV assembly] GO:0009060 [aerobic respiration] GO:0016021 [integral component of membrane] GO:0017004 [cytochrome complex assembly] GO:0031966 [mitochondrial membrane] GO:0044281 [small molecule metabolic process] GO:0045333 [cellular respiration] GO:0048034 [heme O biosynthetic process] GO:0070069 [cytochrome complex] GO:1902600 [hydrogen ion transmembrane transport] Show all	443 aa 48.9 kDa	No	8
COX10-002 ENSP00000397750 ENST00000429152	H7C101 [Direct mapping] Protoheme IX farnesyltransferase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		171 aa 19.7 kDa	No	0